Sqle MGI Mouse Gene Detail - MGI:109296

Symbol

Sqle
Name

squalene epoxidase

Feature Type

protein coding gene
IDs

MGI:109296
NCBI Gene: 20775
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:59186941-59203042 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 25.16 cM
Mapping Data

3 experiments

SNPs within 2kb

560 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109296	protein coding gene	Chr15:59186926-59203042 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021882	protein coding gene	Chr15:58532341-58548435 (+)
A/J	MGP_AJ_G0021842	protein coding gene	Chr15:56257983-56274523 (+)
AKR/J	MGP_AKRJ_G0021823	protein coding gene	Chr15:57804744-57824889 (+)
BALB/cJ	MGP_BALBcJ_G0021849	protein coding gene	Chr15:56471030-56487143 (+)
C3H/HeJ	MGP_C3HHeJ_G0021623	protein coding gene	Chr15:57939105-57955263 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022288	protein coding gene	Chr15:60790542-60809424 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019825	protein coding gene	Chr15:53330209-53346118 (+)
CAST/EiJ	MGP_CASTEiJ_G0021140	protein coding gene	Chr15:58619337-58637531 (+)
CBA/J	MGP_CBAJ_G0021592	protein coding gene	Chr15:62920843-62939517 (+)
DBA/2J	MGP_DBA2J_G0021716	protein coding gene	Chr15:56163466-56179756 (+)
FVB/NJ	MGP_FVBNJ_G0021694	protein coding gene	Chr15:55211821-55229046 (+)
LP/J	MGP_LPJ_G0021786	protein coding gene	Chr15:58402056-58418501 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021718	protein coding gene	Chr15:67950657-67968960 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022311	protein coding gene	Chr15:58211580-58229272 (+)
PWK/PhJ	MGP_PWKPhJ_G0020885	protein coding gene	Chr15:56179244-56196048 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020722	protein coding gene	Chr15:58005849-58022055 (+)
WSB/EiJ	MGP_WSBEiJ_G0021195	protein coding gene	Chr15:58219600-58238771 (+)

Human Ortholog

SQLE, squalene epoxidase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SQLE, squalene epoxidase
Links

HGNC:11279

NCBI Gene ID: 6713

neXtProt AC: NX_Q14534

UniProt: Q14534
Chr Location

8q24.13; chr8:124998497-125022283 (+) GRCh38

MGI Vertebrate Homology

Sqle stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SQLE
Gene Tree

Sqle

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

1
Chemically induced (other)

3
Endonuclease-mediated

3
Gene trapped

4
Radiation induced

2
Targeted

4
Genomic Mutations

5 involving Sqle
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

41 strains or lines available

Mice homozygous for a knock-out allele die before E8.5 with a phenotype consistent with that found in mice with mutations affecting cholesterol synthesis. Mice heterozygous the allele exhibit improved Rett syndrome phenotypes.

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All GO Annotations

24
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

48
cDNA Data

165
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sqle

ZFIN sqlea

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All Sequences

88
RefSeq

2
UniProt

3
CCDS

CCDS27497.1

Ensembl

ENSMUSG00000022351 (Evidence)
NCBI Gene

20775

			Length	Strain/Species	Flank
genomic	20775	NCBI Gene Model \| MGI Sequence Detail	16102	C57BL/6J	± kb
transcript	NM_009270	RefSeq \| MGI Sequence Detail	2748	C57BL/6
polypeptide	P52019	UniProt \| EBI \| MGI Sequence Detail	572	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015601 squalene monooxygenase

(term hierarchy)
EC

1.14.14.17
InterPro Domains

IPR002938 FAD-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR013698 Squalene epoxidase

IPR040125 Squalene monooxygenase

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All nucleic 168

cDNA 165

Primer pair 3

Microarray probesets 3

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MGD-MRK-38341, MGI:2145979

Summaries

All 78

Developmental Gene Expression 7

Diseases 1

Gene Ontology 6

Phenotypes 37
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:347796 Liu Y, et al., Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity. Cell Rep. 2024 Apr 23;43(4):114094

TSS for Sqle:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131363	Chr15:59186879-59186936 (+)	-33 bp
Tssr131364	Chr15:59186937-59186977 (+)	16 bp
Tssr131365	Chr15:59186997-59187022 (+)	69 bp
Tssr131366	Chr15:59187044-59187059 (+)	111 bp
Tssr131367	Chr15:59195458-59195494 (+)	8,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24