Mapkapk2 MGI Mouse Gene Detail - MGI:109298 - MAP kinase-activated protein kinase 2

Symbol

Mapkapk2
Name

MAP kinase-activated protein kinase 2
Synonyms

MAPKAP kinase 2, MK2, Rps6kc1

Feature Type

protein coding gene
IDs

MGI:109298
NCBI Gene: 17164
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:130981437-131025563 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

1050 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109298	protein coding gene	Chr1:130981437-131025580 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016448	protein coding gene	Chr1:134461461-134511229 (-)
A/J	MGP_AJ_G0016431	protein coding gene	Chr1:129492795-129537071 (-)
AKR/J	MGP_AKRJ_G0016396	protein coding gene	Chr1:133308866-133355612 (-)
BALB/cJ	MGP_BALBcJ_G0016391	protein coding gene	Chr1:129824487-129871332 (-)
C3H/HeJ	MGP_C3HHeJ_G0016217	protein coding gene	Chr1:133441562-133486577 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016852	protein coding gene	Chr1:139465327-139510336 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014566	protein coding gene	Chr1:122627918-122674223 (-)
CAST/EiJ	MGP_CASTEiJ_G0015797	protein coding gene	Chr1:132439122-132490781 (-)
CBA/J	MGP_CBAJ_G0016189	protein coding gene	Chr1:144267619-144313848 (-)
DBA/2J	MGP_DBA2J_G0016296	protein coding gene	Chr1:128458990-128508012 (-)
FVB/NJ	MGP_FVBNJ_G0016295	protein coding gene	Chr1:127090713-127138658 (-)
LP/J	MGP_LPJ_G0016367	protein coding gene	Chr1:135774943-135823860 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016320	protein coding gene	Chr1:150034467-150079275 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016888	protein coding gene	Chr1:133068067-133116128 (-)
PWK/PhJ	MGP_PWKPhJ_G0015583	protein coding gene	Chr1:127420047-127469096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015370	protein coding gene	Chr1:132001737-132048717 (-)
WSB/EiJ	MGP_WSBEiJ_G0015859	protein coding gene	Chr1:133055033-133099465 (-)

Human Ortholog

MAPKAPK2, MAPK activated protein kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPKAPK2, MAPK activated protein kinase 2
Synonyms

MAPKAP-K2, MK-2, MK2
Links

HGNC:6887

NCBI Gene ID: 9261

neXtProt AC: NX_P49137

UniProt: P49137
Chr Location

1q32.1; chr1:206684905-206734281 (+) GRCh38

MGI Vertebrate Homology

Mapkapk2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAPKAPK2
Gene Tree

Mapkapk2

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Phenotype Summary

25 phenotypes from 6 alleles in 9 genetic backgrounds
22 phenotypes from multigenic genotypes
91 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Gene trapped

1
Radiation induced

1
Targeted

13
Genomic Mutations

3 involving Mapkapk2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection.

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All GO Annotations

76
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

122
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapkapk2

ZFIN mapkapk2a

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All Sequences

74
RefSeq

2
UniProt

5
CCDS

CCDS15266.1

Ensembl

ENSMUSG00000016528 (Evidence)
NCBI Gene

17164

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016528	Ensembl Gene Model \| MGI Sequence Detail	44127	C57BL/6J	± kb
transcript	ENSMUST00000016672	Ensembl \| MGI Sequence Detail	2854	Not Applicable
polypeptide	ENSMUSP00000016672	Ensembl \| MGI Sequence Detail	386	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010165 MAP kinase-activated protein kinase 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR050205 Calcium-dependent Serine/Threonine Protein Kinases

IPR027442 MAP kinase activated protein kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 4

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MGD-MRK-38343, MGI:2138137

Summaries

All 152

Developmental Gene Expression 6

Gene Ontology 18

Phenotypes 91
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354208 Dong MZ, et al., Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658

TSS for Mapkapk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13549	Chr1:131025845-131025865 (-)	-292 bp
Tssr13548	Chr1:131025587-131025605 (-)	-33 bp
Tssr13547	Chr1:131025563-131025581 (-)	-9 bp
Tssr13546	Chr1:131025536-131025549 (-)	20 bp
Tssr13545	Chr1:131025508-131025520 (-)	49 bp
Tssr13544	Chr1:131025272-131025313 (-)	270 bp
Tssr13543	Chr1:131025168-131025192 (-)	383 bp
Tssr13542	Chr1:131022710-131022722 (-)	2,847 bp
Tssr13541	Chr1:130994035-130994067 (-)	31,512 bp
Tssr13540	Chr1:130986440-130986452 (-)	39,117 bp
Tssr13539	Chr1:130984247-130984271 (-)	41,304 bp
Tssr13538	Chr1:130982617-130982640 (-)	42,934 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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