Lama4 MGI Mouse Gene Detail - MGI:109321

Symbol

Lama4
Name

laminin, alpha 4
Synonyms

laminin [a]4

Feature Type

protein coding gene
IDs

MGI:109321
NCBI Gene: 16775
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:38841511-38986184 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 20.02 cM
Mapping Data

2 experiments

SNPs within 2kb

4606 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109321	protein coding gene	Chr10:38841511-38986184 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017147	protein coding gene	Chr10:37430545-37601087 (+)
A/J	MGP_AJ_G0017124	protein coding gene	Chr10:36455094-36605917 (+)
AKR/J	MGP_AKRJ_G0017084	protein coding gene	Chr10:36956926-37107460 (+)
BALB/cJ	MGP_BALBcJ_G0017087	protein coding gene	Chr10:36487351-36636278 (+)
C3H/HeJ	MGP_C3HHeJ_G0016907	protein coding gene	Chr10:37270554-37428287 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017545	protein coding gene	Chr10:38606484-38763013 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015242	protein coding gene	Chr10:34455533-34598239 (+)
CAST/EiJ	MGP_CASTEiJ_G0016486	protein coding gene	Chr10:37412840-37576491 (+)
CBA/J	MGP_CBAJ_G0016881	protein coding gene	Chr10:40389904-40559500 (+)
DBA/2J	MGP_DBA2J_G0016986	protein coding gene	Chr10:35982094-36129882 (+)
FVB/NJ	MGP_FVBNJ_G0016981	protein coding gene	Chr10:35487785-35633085 (+)
LP/J	MGP_LPJ_G0017063	protein coding gene	Chr10:37412997-37571765 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017011	protein coding gene	Chr10:41270108-41440765 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017581	protein coding gene	Chr10:36940575-37096098 (+)
PWK/PhJ	MGP_PWKPhJ_G0016267	protein coding gene	Chr10:35803872-35953747 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016051	protein coding gene	Chr10:36711560-36866818 (+)
WSB/EiJ	MGP_WSBEiJ_G0016549	protein coding gene	Chr10:37210223-37372162 (+)

Human Ortholog

LAMA4, laminin subunit alpha 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMA4, laminin subunit alpha 4
Synonyms

CMD1JJ, LAMA3, LAMA4*-1
Links

HGNC:6484

NCBI Gene ID: 3910

neXtProt AC: NX_Q16363

UniProt: Q16363
Chr Location

6q21; chr6:112107931-112254985 (-) GRCh38

MGI Vertebrate Homology

Lama4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMA4
Gene Tree

Lama4

Diseases

1 with human LAMA4 associations

				Human Disease	Mouse Models
				dilated cardiomyopathy 1JJ IDs dilated cardiomyopathy 1JJ DOID:0110438 ICD10CM:I42.0 OMIM:615235

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

53 phenotypes from 2 alleles in 3 genetic backgrounds
16 phenotypes from multigenic genotypes
7 images
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Lama4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

114 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects.

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All GO Annotations

14
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

895
Tissues

97
cDNA Data

92
Literature Summary

55

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lama4

ZFIN lama4

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All Sequences

53
RefSeq

2
UniProt

6
CCDS

CCDS35882.1

Ensembl

ENSMUSG00000019846 (Evidence)
NCBI Gene

16775

			Length	Strain/Species	Flank
genomic	16775	NCBI Gene Model \| MGI Sequence Detail	144674	C57BL/6J	± kb
transcript	NM_010681	RefSeq \| MGI Sequence Detail	6046	ZRU/MplStud
polypeptide	P97927	UniProt \| EBI \| MGI Sequence Detail	1816	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009653 laminin subunit alpha-4

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR009254 Laminin alpha, domain I

IPR010307 Laminin domain II

IPR001791 Laminin G domain

IPR050440 Laminin/Netrin Extracellular Matrix

IPR002049 Laminin-type EGF domain

IPR050372 Neurexin-related cell adhesion and synaptic protein
GlyGen

P97927 20 sites, 12 N-linked glycans (10 sites), 1 O-linked glycan (1 site)

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All nucleic 104

Genomic 2

cDNA 97

Primer pair 3

Other 2

Microarray probesets 4

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MGD-MRK-38366

Summaries

All 136

Developmental Gene Expression 55

Gene Ontology 13

Phenotypes 48
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lama4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92966	Chr10:38841188-38841197 (+)	-318 bp
Tssr92967	Chr10:38841543-38841554 (+)	38 bp
Tssr92968	Chr10:38841555-38841572 (+)	53 bp
Tssr92969	Chr10:38841585-38841594 (+)	79 bp
Tssr92970	Chr10:38841612-38841626 (+)	108 bp
Tssr92971	Chr10:38842916-38842947 (+)	1,421 bp
Tssr92972	Chr10:38919606-38919609 (+)	78,097 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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