Fadd MGI Mouse Gene Detail - MGI:109324 - Fas associated via death domain

Symbol

Fadd
Name

Fas associated via death domain
Synonyms

Mort1/FADD

Feature Type

protein coding gene
IDs

MGI:109324
NCBI Gene: 14082
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:144132060-144136178 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 88.85 cM
Mapping Data

2 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109324	protein coding gene	Chr7:144131055-144136200 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033289	protein coding gene	Chr7:149940605-149947458 (-)
A/J	MGP_AJ_G0033272	protein coding gene	Chr7:145584702-145589834 (-)
AKR/J	MGP_AKRJ_G0033203	protein coding gene	Chr7:149686273-149693441 (-)
BALB/cJ	MGP_BALBcJ_G0033272	protein coding gene	Chr7:145367428-145372561 (-)
C3H/HeJ	MGP_C3HHeJ_G0032986	protein coding gene	Chr7:149450590-149456203 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033782	protein coding gene	Chr7:155358393-155363530 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030755	protein coding gene	Chr7:146746496-146751537 (-)
CAST/EiJ	MGP_CASTEiJ_G0032309	protein coding gene	Chr7:141758889-141763834 (-)
CBA/J	MGP_CBAJ_G0032959	protein coding gene	Chr7:160649993-160655751 (-)
DBA/2J	MGP_DBA2J_G0033113	protein coding gene	Chr7:143565185-143570294 (-)
FVB/NJ	MGP_FVBNJ_G0033061	protein coding gene	Chr7:143502373-143507498 (-)
LP/J	MGP_LPJ_G0033205	protein coding gene	Chr7:151470150-151475333 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033095	protein coding gene	Chr7:161188684-161194721 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033800	protein coding gene	Chr7:148656608-148661778 (-)
PWK/PhJ	MGP_PWKPhJ_G0032019	protein coding gene	Chr7:136871323-136876451 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031863	protein coding gene	Chr7:135437157-135442222 (-)
WSB/EiJ	MGP_WSBEiJ_G0032422	protein coding gene	Chr7:149644049-149649249 (-)

Human Ortholog

FADD, Fas associated via death domain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FADD, Fas associated via death domain
Synonyms

GIG3, IMD90, MORT1
Links

HGNC:3573

NCBI Gene ID: 8772

neXtProt AC: NX_Q13158

UniProt: Q13158
Chr Location

11q13.3; chr11:70203296-70207390 (+) GRCh38

MGI Vertebrate Homology

Fadd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FADD
Protein SuperFamily

FADD
Gene Tree

Fadd

Diseases

2 with human FADD associations

				Human Disease	Mouse Models
				leukemia IDs leukemia DOID:1240 DOID:9145 ICD10CM:C95.90 ICD9CM:208 ICD9CM:208.9 MESH:D007938 NCI:C3161 UMLS_CUI:C0023418
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

50 phenotypes from 7 alleles in 9 genetic backgrounds
19 phenotypes from multigenic genotypes
85 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Targeted

12
Transgenic

1
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis.

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All GO Annotations

115
GO References

33

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

82
cDNA Data

36
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fadd

ZFIN fadd

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS22050.1

Ensembl

ENSMUSG00000031077 (Evidence)
NCBI Gene

14082

			Length	Strain/Species	Flank
genomic	14082	NCBI Gene Model \| MGI Sequence Detail	4119	C57BL/6J	± kb
transcript	NM_010175	RefSeq \| MGI Sequence Detail	2876	ZRU/MplStud
polypeptide	Q61160	UniProt \| EBI \| MGI Sequence Detail	205	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002189 FAS-associated death domain protein

(term hierarchy)
PDB

1FAD
InterPro Domains

IPR000488 Death domain

IPR001875 Death effector domain

IPR011029 Death-like domain superfamily

IPR016729 FADD, death domain

IPR049634 FADD, vertebrates

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All nucleic 45

Genomic 7

cDNA 36

Primer pair 2

Microarray probesets 4

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MGD-MRK-38369

Summaries

All 194

Developmental Gene Expression 15

Gene Ontology 33

Phenotypes 85
Earliest

J:113685 Boldin MP, et al., A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 1995 Apr 7;270(14):7795-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fadd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75995	Chr7:144136194-144136211 (-)	-25 bp
Tssr75994	Chr7:144136129-144136191 (-)	18 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24