Bnip1 MGI Mouse Gene Detail - MGI:109328 - BCL2/adenovirus E1B interacting protein 1

Symbol

Bnip1
Name

BCL2/adenovirus E1B interacting protein 1
Synonyms

2010005M06Rik, 5930429G21Rik, MGC:41600

Feature Type

protein coding gene
IDs

MGI:109328
NCBI Gene: 224630
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:27000040-27011539 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.56 cM
Mapping Data

4 experiments

SNPs within 2kb

372 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109328	protein coding gene	Chr17:26999876-27011539 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023406	protein coding gene	Chr17:25980104-25992714 (+)
A/J	MGP_AJ_G0023365	protein coding gene	Chr17:25184024-25195289 (+)
AKR/J	MGP_AKRJ_G0023331	protein coding gene	Chr17:25307806-25320671 (+)
BALB/cJ	MGP_BALBcJ_G0023370	protein coding gene	Chr17:25429235-25440510 (+)
C3H/HeJ	MGP_C3HHeJ_G0023130	protein coding gene	Chr17:25703591-25714840 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023810	protein coding gene	Chr17:27036521-27047557 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021285	protein coding gene	Chr17:22630910-22642337 (+)
CAST/EiJ	MGP_CASTEiJ_G0022631	protein coding gene	Chr17:25642394-25653668 (+)
CBA/J	MGP_CBAJ_G0023105	protein coding gene	Chr17:28027495-28039497 (+)
DBA/2J	MGP_DBA2J_G0023235	protein coding gene	Chr17:24766079-24778263 (+)
FVB/NJ	MGP_FVBNJ_G0023205	protein coding gene	Chr17:24542652-24556132 (+)
LP/J	MGP_LPJ_G0023312	protein coding gene	Chr17:26235548-26249960 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023224	protein coding gene	Chr17:27540060-27552519 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023852	protein coding gene	Chr17:25672039-25686765 (+)
PWK/PhJ	MGP_PWKPhJ_G0022380	protein coding gene	Chr17:23563077-23574849 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022198	protein coding gene	Chr17:23730745-23741300 (+)
WSB/EiJ	MGP_WSBEiJ_G0022694	protein coding gene	Chr17:25719041-25731590 (+)

Human Ortholog

BNIP1, BCL2 interacting protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BNIP1, BCL2 interacting protein 1
Synonyms

NIP1, SEC20, TRG-8
Links

HGNC:1082

NCBI Gene ID: 662

neXtProt AC: NX_Q12981

UniProt: Q12981
Chr Location

5q35.1; chr5:173144442-173164387 (+) GRCh38

MGI Vertebrate Homology

Bnip1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BNIP1
Gene Tree

Bnip1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Radiation induced

2
Targeted

6
Genomic Mutations

2 involving Bnip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

59
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bnip1

ZFIN bnip1a, bnip1b

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All Sequences

61
RefSeq

8
UniProt

5
CCDS

CCDS28555.1

Ensembl

ENSMUSG00000024191 (Evidence)
NCBI Gene

224630

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024191	Ensembl Gene Model \| MGI Sequence Detail	11500	C57BL/6J	± kb
transcript	ENSMUST00000015725	Ensembl \| MGI Sequence Detail	1098	Not Applicable
polypeptide	ENSMUSP00000015725	Ensembl \| MGI Sequence Detail	228	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004779 vesicle transport protein SEC20

(term hierarchy)
InterPro Domains

IPR005606 Sec20
GlyGen

Q6QD59 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 59

cDNA 59

Microarray probesets 4

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MGD-MRK-38373, MGI:1923767, MGI:3026983

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 11
Earliest

J:37511 Boyd JM, et al., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins [see comments] [published erratum appears in Cell 1994 Dec 16;79(6):following 1120]. Cell. 1994 Oct 21;79(2):341-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bnip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143270	Chr17:27000034-27000068 (+)	11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24