Nxn MGI Mouse Gene Detail - MGI:109331

Symbol

Nxn
Name

nucleoredoxin
Synonyms

l11Jus13

Feature Type

protein coding gene
IDs

MGI:109331
NCBI Gene: 18230
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:76148052-76289967 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.92 cM
Mapping Data

5 experiments

SNPs within 2kb

3493 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109331	protein coding gene	Chr11:76148024-76289967 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018733	protein coding gene	Chr11:77081938-77229141 (-)
A/J	MGP_AJ_G0018699	protein coding gene	Chr11:74203923-74345160 (-)
AKR/J	MGP_AKRJ_G0018669	protein coding gene	Chr11:76452683-76603558 (-)
BALB/cJ	MGP_BALBcJ_G0018673	protein coding gene	Chr11:74585178-74727737 (-)
C3H/HeJ	MGP_C3HHeJ_G0018486	protein coding gene	Chr11:76467473-76614246 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019124	protein coding gene	Chr11:79486655-79656539 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016759	protein coding gene	Chr11:71200876-71343062 (-)
CAST/EiJ	MGP_CASTEiJ_G0018040	protein coding gene	Chr11:76861361-77006834 (-)
CBA/J	MGP_CBAJ_G0018456	protein coding gene	Chr11:82987151-83136872 (-)
DBA/2J	MGP_DBA2J_G0018565	protein coding gene	Chr11:73797949-73941484 (-)
FVB/NJ	MGP_FVBNJ_G0018555	protein coding gene	Chr11:73350270-73491836 (-)
LP/J	MGP_LPJ_G0018636	protein coding gene	Chr11:77659569-77805574 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018581	protein coding gene	Chr11:83477348-83631533 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019164	protein coding gene	Chr11:76646336-76791144 (-)
PWK/PhJ	MGP_PWKPhJ_G0017811	protein coding gene	Chr11:74518922-74665444 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017602	protein coding gene	Chr11:76214727-76364848 (-)
WSB/EiJ	MGP_WSBEiJ_G0018093	protein coding gene	Chr11:76467094-76618671 (-)

Human Ortholog

NXN, nucleoredoxin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NXN, nucleoredoxin
Synonyms

NRX, RRS2, TRG-4
Links

HGNC:18008

NCBI Gene ID: 64359

neXtProt AC: NX_Q6DKJ4

UniProt: Q6DKJ4
Chr Location

17p13.3; chr17:799310-979776 (-) GRCh38

MGI Vertebrate Homology

Nxn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NXN
Gene Tree

Nxn

Diseases

1 with human NXN associations

				Human Disease	Mouse Models
				autosomal recessive Robinow syndrome 2 IDs autosomal recessive Robinow syndrome 2 DOID:0060974 OMIM:618529

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

56 phenotypes from 7 alleles in 18 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

285
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

270
Targeted

8
Genomic Mutations

2 involving Nxn
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

502 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die by P1 and exhibit craniofacial bone defects and cleft palate.

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All GO Annotations

20
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1652
Tissues

121
cDNA Data

75
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nxn

ZFIN nxn

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All Sequences

50
RefSeq

2
UniProt

1
CCDS

CCDS25064.1

Ensembl

ENSMUSG00000020844 (Evidence)
NCBI Gene

18230

			Length	Strain/Species	Flank
genomic	18230	NCBI Gene Model \| MGI Sequence Detail	141916	C57BL/6J	± kb
transcript	NM_008750	RefSeq \| MGI Sequence Detail	2728	ZRU/MplStud
polypeptide	P97346	UniProt \| EBI \| MGI Sequence Detail	435	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011539 nucleoredoxin

(term hierarchy)
EC

1.8.1.8
InterPro Domains

IPR041861 Nucleoredoxin, redox inactive TRX-like domain b'

IPR013766 Thioredoxin domain

IPR012336 Thioredoxin-like fold

IPR036249 Thioredoxin-like superfamily

IPR045870 TryX and NRX, thioredoxin domain
GlyGen

P97346 1 site, 1 O-linked glycan (1 site)

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All nucleic 78

Genomic 2

cDNA 76

Microarray probesets 5

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MGD-MRK-38376, MGI:2671280

Summaries

All 75

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 37
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75

TSS for Nxn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109256	Chr11:76289933-76290009 (-)	-4 bp
Tssr109255	Chr11:76289904-76289929 (-)	50 bp
Tssr109254	Chr11:76289889-76289898 (-)	73 bp
Tssr109253	Chr11:76279756-76279764 (-)	10,207 bp
Tssr109251	Chr11:76195002-76195007 (-)	94,962 bp
Tssr109250	Chr11:76178187-76178211 (-)	111,768 bp
Tssr109249	Chr11:76178153-76178172 (-)	111,804 bp
Tssr109248	Chr11:76153917-76153929 (-)	136,044 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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