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Lum Gene Detail
Summary
  • Symbol
    Lum
  • Name
    lumican
  • Synonyms
    Ldc, SLRR2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:109347
    NCBI Gene: 17022
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:97401363-97408565 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 50.32 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109347
 protein coding gene Chr10:97400990-97408565 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017676
 protein coding gene Chr10:99299283-99306481 (+)
A/J MGP_AJ_G0017655
 protein coding gene Chr10:95731685-95738874 (+)
AKR/J MGP_AKRJ_G0017615
 protein coding gene Chr10:98454503-98461701 (+)
BALB/cJ MGP_BALBcJ_G0017619
 protein coding gene Chr10:96028109-96035210 (+)
C3H/HeJ MGP_C3HHeJ_G0017442
 protein coding gene Chr10:98484246-98493293 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018075
 protein coding gene Chr10:102731074-102739325 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015757
 protein coding gene Chr10:91247455-91254625 (+)
CAST/EiJ MGP_CASTEiJ_G0017005
 protein coding gene Chr10:98550561-98557820 (+)
CBA/J MGP_CBAJ_G0017411
 protein coding gene Chr10:106754667-106771352 (+)
DBA/2J MGP_DBA2J_G0017517
 protein coding gene Chr10:94801073-94808374 (+)
FVB/NJ MGP_FVBNJ_G0017510
 protein coding gene Chr10:94065771-94073011 (+)
LP/J MGP_LPJ_G0017591
 protein coding gene Chr10:99889831-99896968 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017540
 protein coding gene Chr10:107916799-107926995 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018113
 protein coding gene Chr10:98384957-98392165 (+)
PWK/PhJ MGP_PWKPhJ_G0016787
 protein coding gene Chr10:94956847-94964057 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016576
 protein coding gene Chr10:97262829-97269996 (+)
WSB/EiJ MGP_WSBEiJ_G0017065
 protein coding gene Chr10:98390270-98398687 (+)



Homology
more
  • Human Ortholog
    LUM, lumican
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LUM, lumican
  • Synonyms
    LDC, SLRR2D
  • Links
    NCBI Gene ID: 4060
    neXtProt AC: NX_P51884
    UniProt: P51884

  • Chr Location
    12q21.33; chr12:91102629-91111494 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lum mouse models; 3 with human LUM associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotypes from multigenic genotypes
    3 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted disruptions of this gene have abnormally large and aberrantly contoured collagen fibrils forming a disorganized matrix in the tendon, skin, cornea and sclera, with consequent reductions in skin tensile strength and corneal clarity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1194
  • Tissues
    131
  • cDNA Data
    119
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17022 NCBI Gene Model | MGI Sequence Detail 7203 C57BL/6J ±  kb
    transcript NM_008524 RefSeq | MGI Sequence Detail 2075 ZRU/MplStud  
    polypeptide P51885 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 4
      cDNA 120
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23785, MGD-MRK-38392
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 33
      Diseases 2
      Gene Ontology 9
      Phenotypes 53
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory