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Atf2 Gene Detail
Summary
  • Symbol
    Atf2
  • Name
    activating transcription factor 2
  • Synonyms
    ATF-2, Creb2, CRE-BP, D130078H02Rik, mXBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109349
    NCBI Gene: 11909
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73646853-73722983 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1259 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109349
 protein coding gene Chr2:73646853-73723094 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025841
 protein coding gene Chr2:74107154-74194309 (-)
A/J MGP_AJ_G0025819
 protein coding gene Chr2:71201849-71282557 (-)
AKR/J MGP_AKRJ_G0025787
 protein coding gene Chr2:73143031-73223671 (-)
BALB/cJ MGP_BALBcJ_G0025813
 protein coding gene Chr2:71390248-71467113 (-)
C3H/HeJ MGP_C3HHeJ_G0025573
 protein coding gene Chr2:73339260-73418325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026260
 protein coding gene Chr2:76314117-76404907 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023663
 protein coding gene Chr2:68628104-68702580 (-)
CAST/EiJ MGP_CASTEiJ_G0025037
 protein coding gene Chr2:73617700-73703496 (-)
CBA/J MGP_CBAJ_G0025554
 protein coding gene Chr2:79105087-79193199 (-)
DBA/2J MGP_DBA2J_G0025685
 protein coding gene Chr2:70792131-70869828 (-)
FVB/NJ MGP_FVBNJ_G0025647
 protein coding gene Chr2:70209581-70287066 (-)
LP/J MGP_LPJ_G0025773
 protein coding gene Chr2:73989433-74072677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025678
 protein coding gene Chr2:81011886-81117796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026317
 protein coding gene Chr2:73238449-73319836 (-)
PWK/PhJ MGP_PWKPhJ_G0024778
 protein coding gene Chr2:70720072-70797141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024586
 protein coding gene Chr2:73468243-73553632 (-)
WSB/EiJ MGP_WSBEiJ_G0025105
 protein coding gene Chr2:73692361-73775905 (-)



Homology
more
  • Human Ortholog
    ATF2, activating transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF2, activating transcription factor 2
  • Synonyms
    CREB-2, CREB2, CRE-BP1, HB16, TREB7
  • Links
    NCBI Gene ID: 1386
    neXtProt AC: NX_P15336
    UniProt: P15336

  • Chr Location
    2q31.1; chr2:175072250-175168382 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Atf2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 6 alleles in 8 genetic backgrounds
    29 phenotypes from multigenic genotypes
    1 images
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased postnatal lethality, skeletal development defects, runting, decreased hearing, inner ear and brain abnormalities, hyperactivity, and ataxia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    139
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    982
  • Tissues
    165
  • cDNA Data
    196
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027104 Ensembl Gene Model | MGI Sequence Detail 76131 C57BL/6J ±  kb
    transcript ENSMUST00000100009 Ensembl | MGI Sequence Detail 3936 Not Applicable  
    polypeptide ENSMUSP00000097588 Ensembl | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000004398 cyclic AMP-dependent transcription factor ATF-2
      (term hierarchy)
    • InterPro Domains
      IPR051027 Basic leucine zipper (bZIP) transcription factors
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR016378 Transcription factor cyclic AMP-dependent, CRE-BP1-type
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    • GlyGen
      P16951 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 211
      cDNA 205
      Primer pair 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-23723, MGD-MRK-38394, MGI:2139537, MGI:2441951, MGI:2678345
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 29
      Diseases 2
      Gene Ontology 30
      Phenotypes 56
    • Earliest
      J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory