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Slc4a2 Gene Detail
Summary
  • Symbol
    Slc4a2
  • Name
    solute carrier family 4 (anion exchanger), member 2
  • Synonyms
    Ae2, B3RP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109351
    NCBI Gene: 20535
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24628834-24645945 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.74 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    342 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109351
 protein coding gene Chr5:24628834-24645948 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029343
 protein coding gene Chr5:22149557-22168617 (+)
A/J MGP_AJ_G0029309
 protein coding gene Chr5:21396589-21413762 (+)
AKR/J MGP_AKRJ_G0029260
 protein coding gene Chr5:22256895-22275219 (+)
BALB/cJ MGP_BALBcJ_G0029320
 protein coding gene Chr5:21909733-21926856 (+)
C3H/HeJ MGP_C3HHeJ_G0029040
 protein coding gene Chr5:22370036-22389464 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029773
 protein coding gene Chr5:23644847-23661958 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027011
 protein coding gene Chr5:19339011-19356019 (+)
CAST/EiJ MGP_CASTEiJ_G0028452
 protein coding gene Chr5:21543921-21562478 (+)
CBA/J MGP_CBAJ_G0029007
 protein coding gene Chr5:24029822-24049861 (+)
DBA/2J MGP_DBA2J_G0029158
 protein coding gene Chr5:21689787-21706829 (+)
FVB/NJ MGP_FVBNJ_G0029116
 protein coding gene Chr5:21058284-21076084 (+)
LP/J MGP_LPJ_G0029242
 protein coding gene Chr5:22549455-22573383 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029145
 protein coding gene Chr5:25153994-25172491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029807
 protein coding gene Chr5:21899126-21917781 (+)
PWK/PhJ MGP_PWKPhJ_G0028176
 protein coding gene Chr5:20767681-20785056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028007
 protein coding gene Chr5:21256021-21273031 (+)
WSB/EiJ MGP_WSBEiJ_G0028532
 protein coding gene Chr5:21964615-21986049 (+)



Homology
more
  • Human Ortholog
    SLC4A2, solute carrier family 4 member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A2, solute carrier family 4 member 2
  • Synonyms
    AE2, BND3L, EPB3L1, HKB3, NBND3, OPTB9
  • Links
    NCBI Gene ID: 6522
    neXtProt AC: NX_P04920
    UniProt: P04920

  • Chr Location
    7q36.1; chr7:151057210-151076527 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC4A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 3 alleles in 5 genetic backgrounds
    9 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice carrying an isoform-specific allele display male infertility associated with disrupted spermiogenesis and germ cell apoptosis. Mice homozygous for a null allele display perinatal and postnatal lethality, loss of gastric acid secretion, failure of tooth eruption, aphagia, and deafness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    11
  • cDNA Data
    115
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20535 NCBI Gene Model | MGI Sequence Detail 17112 C57BL/6J ±  kb
    transcript NM_001421407 RefSeq | MGI Sequence Detail 4505 ZRU/MplStud  
    polypeptide P13808 UniProt | EBI | MGI Sequence Detail 1237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 115
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1168, MGD-MRK-38396
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:320719 Parichha A, et al., Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nat Commun. 2022 Feb 2;13(1):633
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory