Snap23 MGI Mouse Gene Detail - MGI:109356 - synaptosomal-associated protein 23

Symbol

Snap23
Name

synaptosomal-associated protein 23
Synonyms

SNAP-23, Sndt, Syndet

Feature Type

protein coding gene
IDs

MGI:109356
NCBI Gene: 20619
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:120398152-120431736 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.37 cM, cytoband E5
Mapping Data

7 experiments

SNPs within 2kb

743 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109356	protein coding gene	Chr2:120398137-120436829 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026369	protein coding gene	Chr2:123434416-123468817 (+)
A/J	MGP_AJ_G0026330	protein coding gene	Chr2:118384538-118418877 (+)
AKR/J	MGP_AKRJ_G0026309	protein coding gene	Chr2:121687075-121722973 (+)
BALB/cJ	MGP_BALBcJ_G0026343	protein coding gene	Chr2:118622060-118655793 (+)
C3H/HeJ	MGP_C3HHeJ_G0026089	protein coding gene	Chr2:122178016-122214127 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026790	protein coding gene	Chr2:127460318-127497042 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024170	protein coding gene	Chr2:113398341-113433426 (+)
CAST/EiJ	MGP_CASTEiJ_G0025551	protein coding gene	Chr2:122477952-122516408 (+)
CBA/J	MGP_CBAJ_G0026065	protein coding gene	Chr2:131922550-131959588 (+)
DBA/2J	MGP_DBA2J_G0026204	protein coding gene	Chr2:117774382-117810711 (+)
FVB/NJ	MGP_FVBNJ_G0026166	protein coding gene	Chr2:116609615-116643033 (+)
LP/J	MGP_LPJ_G0026305	protein coding gene	Chr2:123700364-123734649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026185	protein coding gene	Chr2:136228575-136268110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026845	protein coding gene	Chr2:121817988-121853705 (+)
PWK/PhJ	MGP_PWKPhJ_G0025287	protein coding gene	Chr2:117378339-117412916 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025086	protein coding gene	Chr2:120999019-121057830 (+)
WSB/EiJ	MGP_WSBEiJ_G0025620	protein coding gene	Chr2:122649465-122683306 (+)

Human Ortholog

SNAP23, synaptosome associated protein 23

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNAP23, synaptosome associated protein 23
Synonyms

HsT17016, SNAP-23, SNAP23A, SNAP23B
Links

HGNC:11131

NCBI Gene ID: 8773

neXtProt AC: NX_O00161

UniProt: O00161
Chr Location

15q15.1-q15.2; chr15:42491129-42545356 (+) GRCh38

MGI Vertebrate Homology

Snap23 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SNAP23
Gene Tree

Snap23

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Phenotype Summary

6 phenotypes from 3 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

1
Gene trapped

41
Radiation induced

1
Targeted

12
Genomic Mutations

2 involving Snap23
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality prior to E3.5.

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All GO Annotations

43
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

12
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snap23

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All Sequences

90
RefSeq

33
UniProt

6
CCDS

CCDS16622.1, CCDS50681.1

Ensembl

ENSMUSG00000027287 (Evidence)
NCBI Gene

20619

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027287	Ensembl Gene Model \| MGI Sequence Detail	33585	C57BL/6J	± kb
transcript	ENSMUST00000116437	Ensembl \| MGI Sequence Detail	2730	Not Applicable
polypeptide	ENSMUSP00000112138	Ensembl \| MGI Sequence Detail	221	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015311 synaptosomal-associated protein 23

(term hierarchy)
InterPro Domains

IPR000928 SNAP-25 domain

IPR000727 Target SNARE coiled-coil homology domain
GlyGen

O09044 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

Genomic 1

cDNA 14

Primer pair 1

Microarray probesets 5

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MGD-MRK-38401, MGI:2138756

Summaries

All 81

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 23
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:349618 Huang M, et al., SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice. Commun Biol. 2024 Jan 5;7(1):34

TSS for Snap23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19709	Chr2:120398133-120398159 (+)	-6 bp
Tssr19710	Chr2:120398168-120398207 (+)	36 bp
Tssr19711	Chr2:120418250-120418253 (+)	20,100 bp
Tssr19712	Chr2:120425320-120425342 (+)	27,179 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24