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Nek2 Gene Detail
Summary
  • Symbol
    Nek2
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109359
    NCBI Gene: 18005
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191553622-191565161 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    382 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109359
 protein coding gene Chr1:191553556-191565162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016948
 protein coding gene Chr1:198899511-198911211 (+)
A/J MGP_AJ_G0016927
 protein coding gene Chr1:190733487-190745139 (+)
AKR/J MGP_AKRJ_G0016892
 protein coding gene Chr1:196406965-196418619 (+)
BALB/cJ MGP_BALBcJ_G0016885
 protein coding gene Chr1:191412523-191424177 (+)
C3H/HeJ MGP_C3HHeJ_G0016709
 protein coding gene Chr1:197246174-197257649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017348
 protein coding gene Chr1:205242396-205254002 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015055
 protein coding gene Chr1:181634086-181645868 (+)
CAST/EiJ MGP_CASTEiJ_G0016292
 protein coding gene Chr1:196838549-196850210 (+)
CBA/J MGP_CBAJ_G0016683
 protein coding gene Chr1:212841398-212855772 (+)
DBA/2J MGP_DBA2J_G0016789
 protein coding gene Chr1:189455961-189468496 (+)
FVB/NJ MGP_FVBNJ_G0016785
 protein coding gene Chr1:187580283-187593042 (+)
LP/J MGP_LPJ_G0016864
 protein coding gene Chr1:200086204-200097683 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016817
 protein coding gene Chr1:219498762-219511946 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017385
 protein coding gene Chr1:196269073-196282678 (+)
PWK/PhJ MGP_PWKPhJ_G0016079
 protein coding gene Chr1:188754323-188766117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015855
 protein coding gene Chr1:195278670-195294354 (+)
WSB/EiJ MGP_WSBEiJ_G0016354
 protein coding gene Chr1:196518975-196532861 (+)



Homology
more
  • Human Ortholog
    NEK2, NIMA related kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK2, NIMA related kinase 2
  • Synonyms
    HsPK21, NEK2A, NLK1, PPP1R111, RP67
  • Links
    NCBI Gene ID: 4751
    neXtProt AC: NX_P51955
    UniProt: P51955

  • Chr Location
    1q32.3; chr1:211658256-211675630 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    31
  • cDNA Data
    26
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18005 NCBI Gene Model | MGI Sequence Detail 11540 C57BL/6J ±  kb
    transcript NM_010892 RefSeq | MGI Sequence Detail 3160 ZRU/MplStud  
    polypeptide O35942 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 26
      Primer pair 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38404, MGI:2138121, MGI:2138656
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 13
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory