Gimap1 MGI Mouse Gene Detail - MGI:109368 - GTPase, IMAP family member 1

Symbol

Gimap1
Name

GTPase, IMAP family member 1
Synonyms

38kDa, IAP38, imap, Imap38

Feature Type

protein coding gene
IDs

MGI:109368
NCBI Gene: 16205
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:48715988-48720729 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.69 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

319 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109368	protein coding gene	Chr6:48715981-48720729 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030710	protein coding gene	Chr6:47696451-47701189 (+)
A/J	MGP_AJ_G0030681	protein coding gene	Chr6:45530512-45536152 (+)
AKR/J	MGP_AKRJ_G0030606	protein coding gene	Chr6:47129348-47134080 (+)
BALB/cJ	MGP_BALBcJ_G0030691	protein coding gene	Chr6:45862581-45867460 (+)
C3H/HeJ	MGP_C3HHeJ_G0030404	protein coding gene	Chr6:47138707-47143365 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031146	protein coding gene	Chr6:48817744-48822440 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028353	protein coding gene	Chr6:43159056-43162594 (+)
CAST/EiJ	MGP_CASTEiJ_G0029808	protein coding gene	Chr6:46860961-46865764 (+)
CBA/J	MGP_CBAJ_G0030379	protein coding gene	Chr6:50839042-50844510 (+)
DBA/2J	MGP_DBA2J_G0030528	protein coding gene	Chr6:45447199-45451902 (+)
FVB/NJ	MGP_FVBNJ_G0030480	protein coding gene	Chr6:45080724-45085458 (+)
LP/J	MGP_LPJ_G0030613	protein coding gene	Chr6:47675772-47681783 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030514	protein coding gene	Chr6:53652147-53658062 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031175	protein coding gene	Chr6:46997016-47002759 (+)
PWK/PhJ	MGP_PWKPhJ_G0029520	protein coding gene	Chr6:44978946-44984131 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029356	protein coding gene	Chr6:46343191-46347907 (+)
WSB/EiJ	MGP_WSBEiJ_G0029885	protein coding gene	Chr6:46998253-47002990 (+)

Human Ortholog

GIMAP1, GTPase, IMAP family member 1

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIMAP1, GTPase, IMAP family member 1
Synonyms

HIMAP1, IAN2, IMAP1, IMAP38
Links

HGNC:23237

NCBI Gene ID: 170575

neXtProt AC: NX_Q8WWP7

UniProt: Q8WWP7
Chr Location

7q36.1; chr7:150716606-150724284 (+) GRCh38

MGI Vertebrate Homology

Gimap1 stringent orthology
1 human;1 mouse;8 zebrafish
HCOP

vertebrate homology predictions: GIMAP1
Gene Tree

Gimap1

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (ENU)

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have defects in the development of mature B and T lymphocytes.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS20113.1

Ensembl

ENSMUSG00000090019 (Evidence)
NCBI Gene

16205

			Length	Strain/Species	Flank
genomic	ENSMUSG00000090019	Ensembl Gene Model \| MGI Sequence Detail	4742	C57BL/6J	± kb
transcript	ENSMUST00000054368	Ensembl \| MGI Sequence Detail	1493	Not Applicable
polypeptide	ENSMUSP00000062108	Ensembl \| MGI Sequence Detail	300	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029507 GTPase IMAP family member 1

(term hierarchy)
InterPro Domains

IPR006703 AIG1-type guanine nucleotide-binding (G) domain

IPR045058 GTPase GIMA/IAN/Toc

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 17

Genomic 1

cDNA 16

Microarray probesets 3

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MGD-MRK-38413

Summaries

All 30

Gene Ontology 5

Phenotypes 6
Earliest

J:38420 Krucken J, et al., Novel gene expressed in spleen cells mediating acquired testosterone-resistant immunity to Plasmodium chabaudi malaria. Biochem Biophys Res Commun. 1997 Jan 3;230(1):167-70
Latest

J:247251 Datta P, et al., Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice. Eur J Immunol. 2017 Jan;47(1):84-93

TSS for Gimap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56201	Chr6:48714266-48714274 (+)	-1,718 bp
Tssr56202	Chr6:48714298-48714328 (+)	-1,675 bp
Tssr56203	Chr6:48715940-48715953 (+)	-41 bp
Tssr56204	Chr6:48715973-48716030 (+)	14 bp
Tssr56205	Chr6:48716802-48716811 (+)	819 bp
Tssr56206	Chr6:48716946-48716958 (+)	964 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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