Noct MGI Mouse Gene Detail - MGI:109382

Symbol

Noct
Name

nocturnin
Synonyms

Ccr4, Ccrn4l

Feature Type

protein coding gene
IDs

MGI:109382
NCBI Gene: 12457
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:51131868-51159065 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 22.12 cM, cytoband B-D
Mapping Data

2 experiments

SNPs within 2kb

810 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109382	protein coding gene	Chr3:51131868-51159075 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027193	protein coding gene	Chr3:49693022-49714632 (+)
A/J	MGP_AJ_G0027153	protein coding gene	Chr3:48237326-48260163 (+)
AKR/J	MGP_AKRJ_G0027122	protein coding gene	Chr3:49190623-49215774 (+)
BALB/cJ	MGP_BALBcJ_G0027165	protein coding gene	Chr3:48092837-48115371 (+)
C3H/HeJ	MGP_C3HHeJ_G0026908	protein coding gene	Chr3:49407296-49431788 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027611	protein coding gene	Chr3:51678682-51704112 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024971	protein coding gene	Chr3:44879228-44900446 (+)
CAST/EiJ	MGP_CASTEiJ_G0026361	protein coding gene	Chr3:49463818-49490697 (+)
CBA/J	MGP_CBAJ_G0026885	protein coding gene	Chr3:53298464-53319950 (+)
DBA/2J	MGP_DBA2J_G0027019	protein coding gene	Chr3:47845135-47872137 (+)
FVB/NJ	MGP_FVBNJ_G0026987	protein coding gene	Chr3:46828799-46850459 (+)
LP/J	MGP_LPJ_G0027131	protein coding gene	Chr3:50440911-50463783 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027005	protein coding gene	Chr3:57493392-57523694 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027670	protein coding gene	Chr3:49120761-49142764 (+)
PWK/PhJ	MGP_PWKPhJ_G0026093	protein coding gene	Chr3:47480123-47504447 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025906	protein coding gene	Chr3:48762956-48785969 (+)
WSB/EiJ	MGP_WSBEiJ_G0026435	protein coding gene	Chr3:49215444-49240972 (+)

Human Ortholog

NOCT, nocturnin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOCT, nocturnin
Synonyms

Ccr4c, CCR4L, CCRN4L, NOC
Links

HGNC:14254

NCBI Gene ID: 25819

neXtProt AC: NX_Q9UK39

UniProt: Q9UK39
Chr Location

4q31.1; chr4:139015781-139045939 (+) GRCh38

MGI Vertebrate Homology

Noct stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NOCT
Gene Tree

Noct

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
1 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

4
Gene trapped

33
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Noct
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are resistant to diet-induced obesity and fatty liver development, show increased circulating glucose levels and increased insulin sensitivity on a standard diet and have impaired glucose tolerance on a high fat diet.

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All GO Annotations

31
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

124
cDNA Data

23
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NOCT

Xenbase noct

ZFIN nocta, noctb

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All Sequences

56
RefSeq

4
UniProt

4
CCDS

CCDS17336.1

Ensembl

ENSMUSG00000023087 (Evidence)
NCBI Gene

12457

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023087	Ensembl Gene Model \| MGI Sequence Detail	27198	C57BL/6J	± kb
transcript	ENSMUST00000023849	Ensembl \| MGI Sequence Detail	3059	Not Applicable
polypeptide	ENSMUSP00000023849	Ensembl \| MGI Sequence Detail	429	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005146 nocturnin

(term hierarchy)
EC

3.1.3.108
InterPro Domains

IPR050410 CCR4/nocturin mRNA turnover and transcription

IPR005135 Endonuclease/exonuclease/phosphatase

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

IPR034965 Nocturnin, deadenylase domain
GlyGen

O35710 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 27

cDNA 24

Primer pair 3

Microarray probesets 4

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MGD-MRK-38427, MGI:2139914

Summaries

All 62

Developmental Gene Expression 4

Diseases 1

Gene Ontology 10

Phenotypes 26
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Noct:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29038	Chr3:51131259-51131276 (+)	-600 bp
Tssr29039	Chr3:51131320-51131333 (+)	-541 bp
Tssr29040	Chr3:51131882-51131896 (+)	21 bp
Tssr29041	Chr3:51131936-51131949 (+)	75 bp
Tssr29042	Chr3:51131966-51131981 (+)	106 bp
Tssr29043	Chr3:51132208-51132228 (+)	350 bp
Tssr29044	Chr3:51132290-51132303 (+)	429 bp
Tssr29045	Chr3:51132333-51132362 (+)	480 bp
Tssr29046	Chr3:51135743-51135748 (+)	3,878 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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