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Atf3 Gene Detail
Summary
  • Symbol
    Atf3
  • Name
    activating transcription factor 3
  • Synonyms
    LRG-21
  • Feature Type
    protein coding gene
  • IDs
    MGI:109384
    NCBI Gene: 11910
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190902493-190915530 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109384
 protein coding gene Chr1:190902493-190950236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016941
 protein coding gene Chr1:198197561-198247965 (-)
A/J MGP_AJ_G0016920
 protein coding gene Chr1:190073543-190121213 (-)
AKR/J MGP_AKRJ_G0016885
 protein coding gene Chr1:195718421-195767790 (-)
BALB/cJ MGP_BALBcJ_G0016878
 protein coding gene Chr1:190751483-190799297 (-)
C3H/HeJ MGP_C3HHeJ_G0016702
 protein coding gene Chr1:196553742-196605209 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017341
 protein coding gene Chr1:204512664-204563744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015048
 protein coding gene Chr1:180967378-181016824 (-)
CAST/EiJ MGP_CASTEiJ_G0016285
 protein coding gene Chr1:196147101-196199563 (-)
CBA/J MGP_CBAJ_G0016676
 protein coding gene Chr1:212092505-212146335 (-)
DBA/2J MGP_DBA2J_G0016782
 protein coding gene Chr1:188798011-188846437 (-)
FVB/NJ MGP_FVBNJ_G0016778
 protein coding gene Chr1:186922594-186971067 (-)
LP/J MGP_LPJ_G0016857
 protein coding gene Chr1:199376050-199426068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016810
 protein coding gene Chr1:218800052-218849132 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017378
 protein coding gene Chr1:195586633-195636857 (-)
PWK/PhJ MGP_PWKPhJ_G0016072
 protein coding gene Chr1:188083849-188132144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015848
 protein coding gene Chr1:194586144-194639813 (-)
WSB/EiJ MGP_WSBEiJ_G0016347
 protein coding gene Chr1:195801287-195852964 (-)



Homology
more
  • Human Ortholog
    ATF3, activating transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF3, activating transcription factor 3
  • Links
    NCBI Gene ID: 467
    neXtProt AC: NX_P18847
    UniProt: P18847

  • Chr Location
    1q32.3; chr1:212565334-212620777 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display enhanced allergen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine and Th2 cytokine responses in lung tissue and lung-derived CD4+ lymphocytes. Primary pancreatic islets are partially protected from cytokine- or nitric oxide-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    979
  • Tissues
    212
  • cDNA Data
    33
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11910 NCBI Gene Model | MGI Sequence Detail 13038 C57BL/6J ±  kb
    transcript NM_007498 RefSeq | MGI Sequence Detail 1981 ZRU/MplStud  
    polypeptide Q60765 UniProt | EBI | MGI Sequence Detail 181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 33
      Primer pair 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38429
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 25
      Gene Ontology 12
      Phenotypes 96
    • Earliest
      J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory