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Reg3a Gene Detail
Summary
  • Symbol
    Reg3a
  • Name
    regenerating islet-derived 3 alpha
  • Synonyms
    RegIII (alpha)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109408
    NCBI Gene: 19694
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:78357692-78360810 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 34.76 cM, cytoband C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109408
 protein coding gene Chr6:78357692-78360822 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030895
 protein coding gene Chr6:79201448-79204568 (+)
A/J MGP_AJ_G0030864
 protein coding gene Chr6:76120998-76124116 (+)
AKR/J MGP_AKRJ_G0030792
 protein coding gene Chr6:78376164-78379266 (+)
BALB/cJ MGP_BALBcJ_G0030874
 protein coding gene Chr6:76194282-76197402 (+)
C3H/HeJ MGP_C3HHeJ_G0030836
 protein coding gene Chr6:105909639-105912757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031334
 protein coding gene Chr6:81321388-81324494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028521
 protein coding gene Chr6:74919861-74923079 (+)
CAST/EiJ MGP_CASTEiJ_G0029982
 protein coding gene Chr6:78311069-78317459 (+)
CBA/J MGP_CBAJ_G0030561
 protein coding gene Chr6:84525493-84528611 (+)
DBA/2J MGP_DBA2J_G0030714
 protein coding gene Chr6:75493632-75496750 (+)
FVB/NJ MGP_FVBNJ_G0030667
 protein coding gene Chr6:74761419-74764533 (+)
LP/J MGP_LPJ_G0030793
 protein coding gene Chr6:79112512-79115618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030703
 protein coding gene Chr6:88526917-88530035 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031358
 protein coding gene Chr6:78205659-78208805 (+)
PWK/PhJ MGP_PWKPhJ_G0029698
 protein coding gene Chr6:74447612-74451245 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029526
 protein coding gene Chr6:77032589-77035583 (+)
WSB/EiJ MGP_WSBEiJ_G0030064
 protein coding gene Chr6:78611906-78615016 (+)



Homology
more
  • Human Ortholog
    REG3A, regenerating family member 3 alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REG3A, regenerating family member 3 alpha
  • Synonyms
    HIP, HIP/PAP, INGAP, PAP, PAP1, PAP-H, PBCGF, REG3, REG-III
  • Links
    NCBI Gene ID: 5068
    neXtProt AC: NX_Q06141
    UniProt: Q06141

  • Chr Location
    2p12; chr2:79157003-79159753 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    5
  • Endonuclease-mediated
    3
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Reg3a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    16 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079516 Ensembl Gene Model | MGI Sequence Detail 3119 C57BL/6J ±  kb
transcript ENSMUST00000101272 Ensembl | MGI Sequence Detail 825 Not Applicable  
polypeptide ENSMUSP00000098829 Ensembl | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR050111 C-type lectin and snaclec domain-containing protein
    IPR018378 C-type lectin, conserved site
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
Molecular
Reagents
less
  • All nucleic 11
    Genomic 2
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38453, MGI:2141615
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:38547 Narushima Y, et al., Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997 Feb 7;185(2):159-68
  • Latest
    J:321983 Yu Y, et al., Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. Nat Commun. 2022 Mar 3;13(1):1151
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory