Faf1 MGI Mouse Gene Detail - MGI:109419

Symbol

Faf1
Name

Fas-associated factor 1
Synonyms

Dffrx, Fam

Feature Type

protein coding gene
IDs

MGI:109419
NCBI Gene: 14084
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:109533873-109821157 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 51.33 cM, cytoband C6
Mapping Data

3 experiments

SNPs within 2kb

5009 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109419	protein coding gene	Chr4:109533785-109821157 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028574	protein coding gene	Chr4:110448158-110762534 (+)
A/J	MGP_AJ_G0028537	protein coding gene	Chr4:106474176-106761975 (+)
AKR/J	MGP_AKRJ_G0028484	protein coding gene	Chr4:109137895-109437166 (+)
BALB/cJ	MGP_BALBcJ_G0028556	protein coding gene	Chr4:106689953-106982183 (+)
C3H/HeJ	MGP_C3HHeJ_G0028270	protein coding gene	Chr4:109889597-110187427 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028996	protein coding gene	Chr4:114433112-114751247 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026287	protein coding gene	Chr4:101766298-102067415 (+)
CAST/EiJ	MGP_CASTEiJ_G0027706	protein coding gene	Chr4:107733373-108045719 (+)
CBA/J	MGP_CBAJ_G0028239	protein coding gene	Chr4:118188601-118517119 (+)
DBA/2J	MGP_DBA2J_G0028387	protein coding gene	Chr4:106100534-106397391 (+)
FVB/NJ	MGP_FVBNJ_G0028355	protein coding gene	Chr4:104975416-105260746 (+)
LP/J	MGP_LPJ_G0028488	protein coding gene	Chr4:110721489-111038689 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028381	protein coding gene	Chr4:123363500-123734531 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029032	protein coding gene	Chr4:109370758-109678017 (+)
PWK/PhJ	MGP_PWKPhJ_G0027432	protein coding gene	Chr4:104391143-104691409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027256	protein coding gene	Chr4:106753472-107077084 (+)
WSB/EiJ	MGP_WSBEiJ_G0027787	protein coding gene	Chr4:109559748-109862749 (+)

Human Ortholog

FAF1, Fas associated factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAF1, Fas associated factor 1
Synonyms

CGI-03, hFAF1, HFAF1s, UBXD12, UBXN3A
Links

HGNC:3578

NCBI Gene ID: 11124

neXtProt AC: NX_Q9UNN5

UniProt: Q9UNN5
Chr Location

1p32.3; chr1:50437028-50960267 (-) GRCh38

MGI Vertebrate Homology

Faf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAF1
Gene Tree

Faf1

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Phenotype Summary

12 phenotypes from 4 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

88
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

77
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Faf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

96 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous fail to develop beyond 2-cell stage. Mice homozygous for a hypomorphic gene trap allele exhibit decreased susceptibility to dopaminergic neuron neurotoxicity.

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All GO Annotations

41
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

73
cDNA Data

92
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase faf1

ZFIN faf1

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All Sequences

44
RefSeq

7
UniProt

1
CCDS

CCDS18468.1

Ensembl

ENSMUSG00000010517 (Evidence)
NCBI Gene

14084

			Length	Strain/Species	Flank
genomic	14084	NCBI Gene Model \| MGI Sequence Detail	287285	C57BL/6J	± kb
transcript	NR_184814	RefSeq \| MGI Sequence Detail	4385	ZRU/MplStud
polypeptide	P54731	UniProt \| EBI \| MGI Sequence Detail	649	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007321 FAS-associated factor 1

(term hierarchy)
InterPro Domains

IPR044541 FAF1, UBA-like domain

IPR049483 Fas-associated factor 1/2-like, UAS domain

IPR033043 FAS-associated factor 1-like, UBX domain

IPR036249 Thioredoxin-like superfamily

IPR006577 UAS

IPR029071 Ubiquitin-like domain superfamily

IPR001012 UBX domain

IPR050730 UBX domain-containing protein
GlyGen

P54731 1 site, 1 O-linked glycan (1 site)

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All nucleic 98

Genomic 1

cDNA 93

Primer pair 4

Microarray probesets 5

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MGD-MRK-38464, MGI:2140134

Summaries

All 62

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 25
Earliest

J:30163 Chu K, et al., A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11894-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Faf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38356	Chr4:109533765-109533787 (+)	-97 bp
Tssr38357	Chr4:109533819-109533840 (+)	-43 bp
Tssr38358	Chr4:109533849-109533899 (+)	1 bp
Tssr38359	Chr4:109533907-109533937 (+)	49 bp
Tssr1260	Chr4:109533963-109533968 (+)	93 bp
Tssr38360	Chr4:109533974-109533997 (+)	113 bp
Tssr38361	Chr4:109588606-109588610 (+)	54,735 bp
Tssr38362	Chr4:109610801-109610805 (+)	76,930 bp
Tssr38363	Chr4:109693565-109693591 (+)	159,705 bp
Tssr38364	Chr4:109700998-109701013 (+)	167,133 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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