Usp34 MGI Mouse Gene Detail - MGI:109473 - ubiquitin specific peptidase 34

Symbol

Usp34
Name

ubiquitin specific peptidase 34
Synonyms

A530081C03Rik, Murr2

Feature Type

protein coding gene
IDs

MGI:109473
NCBI Gene: 17847
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:23256895-23440560 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.29 cM
Mapping Data

1 experiment

SNPs within 2kb

3135 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109473	protein coding gene	Chr11:23256433-23440560 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018086	protein coding gene	Chr11:21048700-21249579 (+)
A/J	MGP_AJ_G0018059	protein coding gene	Chr11:20231582-20421774 (+)
AKR/J	MGP_AKRJ_G0018023	protein coding gene	Chr11:20955161-21148140 (+)
BALB/cJ	MGP_BALBcJ_G0018027	protein coding gene	Chr11:20373250-20559837 (+)
C3H/HeJ	MGP_C3HHeJ_G0017841	protein coding gene	Chr11:20839113-21031388 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018479	protein coding gene	Chr11:21913364-22108498 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016137	protein coding gene	Chr11:19125268-19315496 (+)
CAST/EiJ	MGP_CASTEiJ_G0017402	protein coding gene	Chr11:20873128-21063565 (+)
CBA/J	MGP_CBAJ_G0017815	protein coding gene	Chr11:22873324-23093221 (+)
DBA/2J	MGP_DBA2J_G0017925	protein coding gene	Chr11:20162600-20347872 (+)
FVB/NJ	MGP_FVBNJ_G0017917	protein coding gene	Chr11:19940551-20126211 (+)
LP/J	MGP_LPJ_G0017996	protein coding gene	Chr11:21152570-21347341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017943	protein coding gene	Chr11:23346279-23620264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018520	protein coding gene	Chr11:21062939-21263843 (+)
PWK/PhJ	MGP_PWKPhJ_G0017183	protein coding gene	Chr11:20203079-20393581 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016980	protein coding gene	Chr11:20822955-21014306 (+)
WSB/EiJ	MGP_WSBEiJ_G0017456	protein coding gene	Chr11:20701668-20899785 (+)

Human Ortholog

USP34, ubiquitin specific peptidase 34

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP34, ubiquitin specific peptidase 34
Links

HGNC:20066

NCBI Gene ID: 9736

neXtProt AC: NX_Q70CQ2

UniProt: Q70CQ2
Chr Location

2p15; chr2:61187463-61471087 (-) GRCh38

MGI Vertebrate Homology

Usp34 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP34
Gene Tree

Usp34

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

63
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

57
Targeted

2
Genomic Mutations

1 involving Usp34
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

190 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in early limb bud exhibit reduced osteogenic differentiation and bone formation.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp34

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All Sequences

78
RefSeq

16
UniProt

5
CCDS

CCDS56763.1

Ensembl

ENSMUSG00000056342 (Evidence)
NCBI Gene

17847

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056342	Ensembl Gene Model \| MGI Sequence Detail	183666	C57BL/6J	± kb
transcript	ENSMUST00000137823	Ensembl \| MGI Sequence Detail	11363	Not Applicable
polypeptide	ENSMUSP00000120747	Ensembl \| MGI Sequence Detail	3602	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017173 ubiquitin carboxyl-terminal hydrolase 34

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR016024 Armadillo-type fold

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050164 Ubiquitin carboxyl-terminal hydrolases

IPR021905 Ubiquitin C-terminal hydrolase-like, DUF3517

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain
GlyGen

Q6ZQ93 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 19

Genomic 1

cDNA 17

Primer pair 1

Microarray probesets 2

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MGD-MRK-38518, MGI:2441806

Summaries

All 40

Gene Ontology 4

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:311501 Li Q, et al., Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-kappaB Signaling. J Bone Miner Res. 2020;35(8):1597-1608

TSS for Usp34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100620	Chr11:23256428-23256472 (+)	-445 bp
Tssr100621	Chr11:23256499-23256602 (+)	-344 bp
Tssr3446	Chr11:23256690-23256718 (+)	-191 bp
Tssr100622	Chr11:23256736-23256747 (+)	-153 bp
Tssr100623	Chr11:23256884-23256906 (+)	0 bp
Tssr100624	Chr11:23256910-23256937 (+)	29 bp
Tssr100625	Chr11:23351595-23351605 (+)	94,705 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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