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Lgals9 Gene Detail
Summary
  • Symbol
    Lgals9
  • Name
    lectin, galactose binding, soluble 9
  • Synonyms
    gal-9, galectin-9, LGALS35, Lgals5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109496
    NCBI Gene: 16859
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78853805-78875750 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    664 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109496
 protein coding gene Chr11:78853800-78875772 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018792
 protein coding gene Chr11:80024187-80046147 (-)
A/J MGP_AJ_G0018759
 protein coding gene Chr11:76950208-76972757 (-)
AKR/J MGP_AKRJ_G0018729
 protein coding gene Chr11:79257893-79279872 (-)
BALB/cJ MGP_BALBcJ_G0018732
 protein coding gene Chr11:77361767-77383730 (-)
C3H/HeJ MGP_C3HHeJ_G0018546
 protein coding gene Chr11:79306044-79331181 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019184
 protein coding gene Chr11:82486982-82510322 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016819
 protein coding gene Chr11:73907905-73930659 (-)
CAST/EiJ MGP_CASTEiJ_G0018101
 protein coding gene Chr11:79772815-79795127 (-)
CBA/J MGP_CBAJ_G0018517
 protein coding gene Chr11:86074906-86097062 (-)
DBA/2J MGP_DBA2J_G0018625
 protein coding gene Chr11:76516505-76538514 (-)
FVB/NJ MGP_FVBNJ_G0018614
 protein coding gene Chr11:76110516-76132526 (-)
LP/J MGP_LPJ_G0018695
 protein coding gene Chr11:80540255-80562309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018641
 protein coding gene Chr11:86463398-86485425 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019224
 protein coding gene Chr11:79517724-79539739 (-)
PWK/PhJ MGP_PWKPhJ_G0017871
 protein coding gene Chr11:77321211-77343363 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017662
 protein coding gene Chr11:79132995-79158809 (-)
WSB/EiJ MGP_WSBEiJ_G0018153
 protein coding gene Chr11:79341988-79365553 (-)



Homology
more
  • Human Ortholog
    LGALS9, galectin 9
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGALS9, galectin 9
  • Synonyms
    HUAT, LGALS9A
  • Links
    NCBI Gene ID: 3965
    neXtProt AC: NX_O00182
    UniProt: O00182

  • Chr Location
    17q11.2; chr17:27629798-27649560 (+)  GRCh38
  • Human Ortholog
    LGALS9B, galectin 9B
  • Links
    NCBI Gene ID: 284194
    neXtProt AC: NX_Q3B8N2
    UniProt: Q3B8N2

  • Chr Location
    17p11.2; chr17:20449395-20467539 (-)  GRCh38
  • Human Ortholog
    LGALS9C, galectin 9C
  • Synonyms
    Gal-9B, LGALS9B
  • Links
    NCBI Gene ID: 654346
    neXtProt AC: NX_Q6DKI2
    UniProt: Q6DKI2

  • Chr Location
    17p11.2; chr17:18476737-18494945 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to collagen-induced arthritis, increased T-helper 1 cells and decreased regulatory T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    45
  • cDNA Data
    150
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16859 NCBI Gene Model | MGI Sequence Detail 21946 C57BL/6J ±  kb
    transcript NM_010708 RefSeq | MGI Sequence Detail 1586 C57BL/6NCrl  
    polypeptide O08573 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 154
      Genomic 1
      cDNA 151
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24103, MGD-MRK-39495, MGI:103231, MGI:2143968, MGI:2144080, MGI:2144105
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 6
      Gene Ontology 14
      Phenotypes 43
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350213 Fu H, et al., The glucose transporter 2 regulates CD8(+) T cell function via environment sensing. Nat Metab. 2023 Nov;5(11):1969-1985
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory