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Gata5 Gene Detail
Summary
  • Symbol
    Gata5
  • Name
    GATA binding protein 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109497
    NCBI Gene: 14464
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179966926-179976492 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 102.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    324 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109497
 protein coding gene Chr2:179966881-179977296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026993
 protein coding gene Chr2:186841151-186850715 (-)
A/J MGP_AJ_G0026959
 protein coding gene Chr2:179165604-179175167 (-)
AKR/J MGP_AKRJ_G0026929
 protein coding gene Chr2:184538549-184548112 (-)
BALB/cJ MGP_BALBcJ_G0026968
 protein coding gene Chr2:179629950-179639514 (-)
C3H/HeJ MGP_C3HHeJ_G0026709
 protein coding gene Chr2:184877935-184887499 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027414
 protein coding gene Chr2:192233705-192243271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024779
 protein coding gene Chr2:169854570-169865787 (-)
CAST/EiJ MGP_CASTEiJ_G0026168
 protein coding gene Chr2:183127787-183137355 (-)
CBA/J MGP_CBAJ_G0026686
 protein coding gene Chr2:199237234-199246798 (-)
DBA/2J MGP_DBA2J_G0026824
 protein coding gene Chr2:178263937-178273503 (-)
FVB/NJ MGP_FVBNJ_G0026790
 protein coding gene Chr2:176871629-176881203 (-)
LP/J MGP_LPJ_G0026925
 protein coding gene Chr2:186847080-186856691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026809
 protein coding gene Chr2:201843387-201852951 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027473
 protein coding gene Chr2:184493632-184503196 (-)
PWK/PhJ MGP_PWKPhJ_G0025904
 protein coding gene Chr2:175773549-175783290 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025704
 protein coding gene Chr2:180987594-180997173 (-)
WSB/EiJ MGP_WSBEiJ_G0026240
 protein coding gene Chr2:185475265-185484828 (-)



Homology
more
  • Human Ortholog
    GATA5, GATA binding protein 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATA5, GATA binding protein 5
  • Synonyms
    bB379O24.1, CHTD5, GATAS
  • Links
    NCBI Gene ID: 140628
    neXtProt AC: NX_Q9BWX5
    UniProt: Q9BWX5

  • Chr Location
    20q13.33; chr20:62463497-62475995 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gata5 mouse models; 8 with human GATA5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 4 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    7 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene are viable and fertile and appear to be normal. Females, on the other hand, have abnormalities of the external genitalia, most apparently reduced distance between anus and vagina, and experience reduced fertility due to vaginal tract obstructions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    86
  • cDNA Data
    10
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015627 Ensembl Gene Model | MGI Sequence Detail 9567 C57BL/6J ±  kb
    transcript ENSMUST00000015771 Ensembl | MGI Sequence Detail 3277 Not Applicable  
    polypeptide ENSMUSP00000015771 Ensembl | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 13
      Primer pair 11
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39496
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 43
      Diseases 1
      Gene Ontology 13
      Phenotypes 9
    • Earliest
      J:38927 Morrisey EE, et al., GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol. 1997 Mar 1;183(1):21-36
    • Latest
      J:306955 Moazzen H, et al., NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development. Oxid Med Cell Longev. 2020;2020:1679045
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory