Cdh12 MGI Mouse Gene Detail - MGI:109503

Symbol

Cdh12
Name

cadherin 12
Synonyms

Br-cadherin

Feature Type

protein coding gene
IDs

MGI:109503
NCBI Gene: 215654
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr15:20449351-21589619 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 8.25 cM

SNPs within 2kb

30455 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109503	protein coding gene	Chr15:20448967-21598668 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021745	protein coding gene	Chr15:18857900-19349510 (+)
A/J	MGP_AJ_G0021705	protein coding gene	Chr15:18145968-18617991 (+)
AKR/J	MGP_AKRJ_G0021683	protein coding gene	Chr15:18591958-19077381 (+)
BALB/cJ	MGP_BALBcJ_G0021712	protein coding gene	Chr15:18175148-18664201 (+)
C3H/HeJ	MGP_C3HHeJ_G0021488	protein coding gene	Chr15:18572765-19079170 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022151	protein coding gene	Chr15:19645198-20167006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019691	protein coding gene	Chr15:16919095-17379911 (+)
CAST/EiJ	MGP_CASTEiJ_G0021004	protein coding gene	Chr15:18925310-19423168 (+)
CBA/J	MGP_CBAJ_G0021457	protein coding gene	Chr15:20290595-20841369 (+)
DBA/2J	MGP_DBA2J_G0021581	protein coding gene	Chr15:17979209-18455038 (+)
FVB/NJ	MGP_FVBNJ_G0021559	protein coding gene	Chr15:17616636-18070673 (+)
LP/J	MGP_LPJ_G0021649	protein coding gene	Chr15:18765879-19264471 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021584	protein coding gene	Chr15:22236456-22801233 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022174	protein coding gene	Chr15:18742484-19238332 (+)
PWK/PhJ	MGP_PWKPhJ_G0020747	protein coding gene	Chr15:18169998-18640234 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020585	protein coding gene	Chr15:18554170-19048194 (+)
WSB/EiJ	MGP_WSBEiJ_G0021060	protein coding gene	Chr15:18750927-19265499 (+)

Human Ortholog

CDH12, cadherin 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDH12, cadherin 12
Synonyms

CDHB
Links

HGNC:1751

NCBI Gene ID: 1010

neXtProt AC: NX_P55289

UniProt: P55289
Chr Location

5p14.3; chr5:21750673-22853344 (-) GRCh38

MGI Vertebrate Homology

Cdh12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDH12
Gene Tree

Cdh12

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Cdh12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

937
Tissues

121
cDNA Data

7
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDH12

Xenbase cdh12

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All Sequences

52
RefSeq

24
UniProt

1
CCDS

CCDS27396.1

Ensembl

ENSMUSG00000040452 (Evidence)
NCBI Gene

215654

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040452	Ensembl Gene Model \| MGI Sequence Detail	1140269	C57BL/6J	± kb
transcript	ENSMUST00000075132	Ensembl \| MGI Sequence Detail	5636	Not Applicable
polypeptide	ENSMUSP00000074632	Ensembl \| MGI Sequence Detail	794	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005231 cadherin-12

(term hierarchy)
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR000233 Cadherin, Y-type LIR-motif

IPR027397 Catenin binding domain superfamily
GlyGen

Q5RJH3 4 sites, 6 N-linked glycans (4 sites)

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All nucleic 14

cDNA 8

Primer pair 5

Other 1

Microarray probesets 1

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MGD-MRK-39502

Summaries

All 42

Developmental Gene Expression 15

Gene Ontology 3

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059

TSS for Cdh12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130771	Chr15:20491556-20491560 (+)	42,207 bp
Tssr130772	Chr15:20520596-20520597 (+)	71,246 bp
Tssr130773	Chr15:20538466-20538486 (+)	89,125 bp
Tssr130774	Chr15:20568855-20568862 (+)	119,508 bp
Tssr130775	Chr15:20744321-20744324 (+)	294,972 bp
Tssr130776	Chr15:20861446-20861447 (+)	412,096 bp
Tssr4559	Chr15:20931432-20931433 (+)	482,082 bp
Tssr130777	Chr15:21035129-21035133 (+)	585,780 bp
Tssr130778	Chr15:21097780-21097781 (+)	648,430 bp
Tssr130779	Chr15:21111428-21111442 (+)	662,084 bp
Tssr130780	Chr15:21329485-21329492 (+)	880,138 bp
Tssr130781	Chr15:21367550-21367554 (+)	918,201 bp
Tssr130782	Chr15:21410872-21410873 (+)	961,522 bp
Tssr130783	Chr15:21489914-21489918 (+)	1,040,565 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24