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Sftpc Gene Detail
Summary
  • Symbol
    Sftpc
  • Name
    surfactant associated protein C
  • Synonyms
    Bricd6, pro-SpC, Sftp-2, Sftp2, SP-C, SPC
  • Feature Type
    protein coding gene
  • IDs
    MGI:109517
    NCBI Gene: 20389
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70758389-70761521 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109517
 protein coding gene Chr14:70758381-70761521 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021540
 protein coding gene Chr14:65174522-65177672 (-)
A/J MGP_AJ_G0021499
 protein coding gene Chr14:63790263-63793403 (-)
AKR/J MGP_AKRJ_G0021475
 protein coding gene Chr14:65702202-65705342 (-)
BALB/cJ MGP_BALBcJ_G0021505
 protein coding gene Chr14:63553228-63556368 (-)
C3H/HeJ MGP_C3HHeJ_G0021282
 protein coding gene Chr14:65416873-65420013 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021944
 protein coding gene Chr14:68088048-68091188 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019484
 protein coding gene Chr14:61627807-61631011 (-)
CAST/EiJ MGP_CASTEiJ_G0020799
 protein coding gene Chr14:62011203-62014380 (-)
CBA/J MGP_CBAJ_G0021249
 protein coding gene Chr14:70227873-70231013 (-)
DBA/2J MGP_DBA2J_G0021372
 protein coding gene Chr14:63173922-63177062 (-)
FVB/NJ MGP_FVBNJ_G0021351
 protein coding gene Chr14:62604080-62607220 (-)
LP/J MGP_LPJ_G0021443
 protein coding gene Chr14:66416939-66420089 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021380
 protein coding gene Chr14:69116054-69119194 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021968
 protein coding gene Chr14:64965129-64968269 (-)
PWK/PhJ MGP_PWKPhJ_G0020543
 protein coding gene Chr14:59941157-59944442 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020376
 protein coding gene Chr14:60891691-60894804 (-)
WSB/EiJ MGP_WSBEiJ_G0020852
 protein coding gene Chr14:65277248-65280399 (-)



Homology
more
  • Human Ortholog
    SFTPC, surfactant protein C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFTPC, surfactant protein C
  • Synonyms
    BRICD6, PSP-C, SFTP2, SMDP2, SP5, SP-C
  • Links
    NCBI Gene ID: 6440
    neXtProt AC: NX_P11686
    UniProt: P11686

  • Chr Location
    8p21.3; chr8:22156913-22164479 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sftpc mouse models; 9 with human SFTPC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 images
    168 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display respiratory abnormalities similar to emphysema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1280
  • Tissues
    68
  • cDNA Data
    908
  • Literature Summary
    378
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022097 Ensembl Gene Model | MGI Sequence Detail 3133 C57BL/6J ±  kb
    transcript ENSMUST00000022692 Ensembl | MGI Sequence Detail 792 Not Applicable  
    polypeptide ENSMUSP00000022692 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 952
      Genomic 1
      cDNA 914
      Primer pair 26
      Other 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14378, MGD-MRK-14381, MGD-MRK-39516
    References
    more
    • Summaries
      All 577
      Developmental Gene Expression 378
      Diseases 1
      Gene Ontology 7
      Phenotypes 168
    • Earliest
      J:10878 Glasser SW, et al., Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem. 1990 Dec 15;265(35):21986-91
    • Latest
      J:359043 Tan Q, et al., Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis. JCI Insight. 2024 Jul 16;9(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory