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Htr2a Gene Detail
Summary
  • Symbol
    Htr2a
  • Name
    5-hydroxytryptamine (serotonin) receptor 2A
  • Synonyms
    5-HT2A receptor, Htr-2, Htr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109521
    NCBI Gene: 15558
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:74878314-74944299 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 39.37 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1907 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109521
 protein coding gene Chr14:74878280-74946934 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021562
 protein coding gene Chr14:69425435-69494424 (+)
A/J MGP_AJ_G0021520
 protein coding gene Chr14:67883603-67949776 (+)
AKR/J MGP_AKRJ_G0021497
 protein coding gene Chr14:69905488-69977807 (+)
BALB/cJ MGP_BALBcJ_G0021527
 protein coding gene Chr14:67678215-67744865 (+)
C3H/HeJ MGP_C3HHeJ_G0021304
 protein coding gene Chr14:69642625-69714006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021967
 protein coding gene Chr14:72457599-72542357 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019505
 protein coding gene Chr14:65539741-65605662 (+)
CAST/EiJ MGP_CASTEiJ_G0020821
 protein coding gene Chr14:66285912-66361789 (+)
CBA/J MGP_CBAJ_G0021272
 protein coding gene Chr14:74803745-74875845 (+)
DBA/2J MGP_DBA2J_G0021395
 protein coding gene Chr14:67302360-67370948 (+)
FVB/NJ MGP_FVBNJ_G0021373
 protein coding gene Chr14:66631763-66698088 (+)
LP/J MGP_LPJ_G0021465
 protein coding gene Chr14:70590504-70659758 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021400
 protein coding gene Chr14:73591334-73664610 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021990
 protein coding gene Chr14:69187474-69257199 (+)
PWK/PhJ MGP_PWKPhJ_G0020564
 protein coding gene Chr14:64029230-64096201 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020400
 protein coding gene Chr14:65136638-65210616 (+)
WSB/EiJ MGP_WSBEiJ_G0020874
 protein coding gene Chr14:69520137-69591193 (+)



Homology
more
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
  • Synonyms
    5-HT2A, HTR2
  • Links
    NCBI Gene ID: 3356
    neXtProt AC: NX_P28223
    UniProt: P28223

  • Chr Location
    13q14.2; chr13:46831546-46898082 (-)  GRCh38
Human Diseases
more
  • Diseases
    13 with human HTR2A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 5 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    121
  • cDNA Data
    12
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15558 NCBI Gene Model | MGI Sequence Detail 65986 C57BL/6J ±  kb
    transcript NM_172812 RefSeq | MGI Sequence Detail 2937 ZRU/MplStud  
    polypeptide P35363 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 13
      cDNA 14
      Primer pair 4
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:10923 Hsieh CL, et al., The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov;16(6):567-74
    • Latest
      J:341875 Vargas MV, et al., Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 Feb 17;379(6633):700-706
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory