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Trpc6 Gene Detail
Summary
  • Symbol
    Trpc6
  • Name
    transient receptor potential cation channel, subfamily C, member 6
  • Synonyms
    mtrp6, Trrp6
  • Feature Type
    protein coding gene
  • IDs
    MGI:109523
    NCBI Gene: 22068
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:8544143-8680742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3447 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109523
 protein coding gene Chr9:8543868-8680753 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034335
 protein coding gene Chr9:5438888-5567266 (+)
A/J MGP_AJ_G0034313
 protein coding gene Chr9:5532000-5673482 (+)
AKR/J MGP_AKRJ_G0034241
 protein coding gene Chr9:5368264-5502343 (+)
BALB/cJ MGP_BALBcJ_G0034307
 protein coding gene Chr9:5258214-5399833 (+)
C3H/HeJ MGP_C3HHeJ_G0034018
 protein coding gene Chr9:5603870-5730011 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034829
 protein coding gene Chr9:5635563-5770769 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031767
 protein coding gene Chr9:4713952-4830178 (+)
CAST/EiJ MGP_CASTEiJ_G0033346
 protein coding gene Chr9:5565131-5685702 (+)
CBA/J MGP_CBAJ_G0033991
 protein coding gene Chr9:5816267-5955030 (+)
DBA/2J MGP_DBA2J_G0034148
 protein coding gene Chr9:5401638-5531691 (+)
FVB/NJ MGP_FVBNJ_G0034093
 protein coding gene Chr9:5154296-5280153 (+)
LP/J MGP_LPJ_G0034234
 protein coding gene Chr9:5415233-5575431 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034137
 protein coding gene Chr9:6517349-6668576 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034848
 protein coding gene Chr9:5366109-5497462 (+)
PWK/PhJ MGP_PWKPhJ_G0033049
 protein coding gene Chr9:5466574-5603104 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032887
 protein coding gene Chr9:5600860-5726268 (+)
WSB/EiJ MGP_WSBEiJ_G0033461
 protein coding gene Chr9:5381640-5506411 (+)



Homology
more
  • Human Ortholog
    TRPC6, transient receptor potential cation channel subfamily C member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC6, transient receptor potential cation channel subfamily C member 6
  • Synonyms
    FSGS2, TRP6
  • Links
    NCBI Gene ID: 7225
    neXtProt AC: NX_Q9Y210
    UniProt: Q9Y210

  • Chr Location
    11q22.1; chr11:101451564-101872562 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trpc6 mouse models; 4 with human TRPC6 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null targeted mutation are viable and fertile and exhibit no overt abnormal phenotype. Another knockout results in an increase in thermal nociceptive response latency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1224
  • Tissues
    75
  • cDNA Data
    10
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031997 Ensembl Gene Model | MGI Sequence Detail 136600 C57BL/6J ±  kb
    transcript ENSMUST00000050433 Ensembl | MGI Sequence Detail 3259 Not Applicable  
    polypeptide ENSMUSP00000057965 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016696 short transient receptor potential channel 6
      (term hierarchy)
    • PDB
      6CV9
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR013555 Transient receptor ion channel domain
      IPR002153 Transient receptor potential channel, canonical
      IPR005462 Transient receptor potential channel, canonical 6
    • GlyGen
      Q61143 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 11
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39522, MGI:2143254
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 12
      Phenotypes 88
    • Earliest
      J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
    • Latest
      J:349094 Lin Y, et al., TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer. Front Pharmacol. 2024;15:1392328
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory