Sf1 MGI Mouse Gene Detail - MGI:1095403

Symbol

Sf1
Name

splicing factor 1
Synonyms

CW17R, MZFM, WBP4, Zfp162

Feature Type

protein coding gene
IDs

MGI:1095403
NCBI Gene: 22668
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr19:6413952-6428060 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.48 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095403	protein coding gene	Chr19:6413720-6428060 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024761	protein coding gene	Chr19:3414506-3430211 (+)
A/J	MGP_AJ_G0024727	protein coding gene	Chr19:3228881-3243221 (+)
AKR/J	MGP_AKRJ_G0024700	protein coding gene	Chr19:3326568-3340908 (+)
BALB/cJ	MGP_BALBcJ_G0024727	protein coding gene	Chr19:3227206-3241708 (+)
C3H/HeJ	MGP_C3HHeJ_G0024495	protein coding gene	Chr19:3347357-3361729 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025173	protein coding gene	Chr19:3468309-3482649 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022607	protein coding gene	Chr19:3152490-3166856 (+)
CAST/EiJ	MGP_CASTEiJ_G0023967	protein coding gene	Chr19:3371525-3387389 (+)
CBA/J	MGP_CBAJ_G0024467	protein coding gene	Chr19:3640449-3654981 (+)
DBA/2J	MGP_DBA2J_G0024594	protein coding gene	Chr19:3218281-3232717 (+)
FVB/NJ	MGP_FVBNJ_G0024560	protein coding gene	Chr19:3234706-3249254 (+)
LP/J	MGP_LPJ_G0024680	protein coding gene	Chr19:3382463-3396802 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024589	protein coding gene	Chr19:3462598-3476929 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025221	protein coding gene	Chr19:3352209-3366545 (+)
PWK/PhJ	MGP_PWKPhJ_G0023713	protein coding gene	Chr19:3252308-3267056 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023518	protein coding gene	Chr19:3311598-3325933 (+)
WSB/EiJ	MGP_WSBEiJ_G0024029	protein coding gene	Chr19:3365835-3380174 (+)

Human Ortholog

SF1, splicing factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SF1, splicing factor 1
Synonyms

BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162
Links

HGNC:12950

NCBI Gene ID: 7536

neXtProt AC: NX_Q15637

UniProt: Q15637
Chr Location

11q13.1; chr11:64764606-64778786 (-) GRCh38

MGI Vertebrate Homology

Sf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SF1
Gene Tree

Sf1

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Endonuclease-mediated

2
Gene trapped

61
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a gene trapped allele exhibit embryonic lethalilty prior to E8.5. Mice heterozygous for a gene trapped allele exhibit increased incidence of chemically induced tumors.

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All GO Annotations

23
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

95
cDNA Data

234
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sf1

ZFIN sf1

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All Sequences

119
RefSeq

34
UniProt

13
CCDS

CCDS50368.1, CCDS50369.1

Ensembl

ENSMUSG00000024949 (Evidence)
NCBI Gene

22668

			Length	Strain/Species	Flank
genomic	22668	NCBI Gene Model \| MGI Sequence Detail	14109	C57BL/6J	± kb
transcript	NM_001403448	RefSeq \| MGI Sequence Detail	4125	C57BL/6
polypeptide	Q64213	UniProt \| EBI \| MGI Sequence Detail	653	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000014730 splicing factor 1

(term hierarchy)
InterPro Domains

IPR045071 KH domain-containing BBP-like

IPR004087 K Homology domain

IPR036612 K Homology domain, type 1 superfamily

IPR032570 Splicing factor 1, helix-hairpin domain

IPR047086 Splicing factor 1, helix-hairpin domain superfamily

IPR001878 Zinc finger, CCHC-type
GlyGen

Q64213 6 sites, 1 O-linked glycan (6 sites)

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All nucleic 242

Genomic 4

cDNA 234

Primer pair 4

Microarray probesets 6

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MGI:2147764

Summaries

All 65

Developmental Gene Expression 15

Gene Ontology 10

Phenotypes 12
Earliest

J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
Latest

J:302708 Liu HB, et al., RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Adv Sci (Weinh). 2019 Aug 7;6(15):1900295

TSS for Sf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154630	Chr19:6413701-6413734 (+)	-234 bp
Tssr154631	Chr19:6413756-6413767 (+)	-190 bp
Tssr154632	Chr19:6413926-6413971 (+)	-3 bp
Tssr154633	Chr19:6413976-6413990 (+)	31 bp
Tssr154634	Chr19:6414019-6414072 (+)	94 bp
Tssr154635	Chr19:6414608-6414698 (+)	701 bp
Tssr154636	Chr19:6422612-6422628 (+)	8,668 bp
Tssr154637	Chr19:6423671-6423690 (+)	9,729 bp
Tssr154638	Chr19:6423700-6423748 (+)	9,772 bp
Tssr154639	Chr19:6424801-6424821 (+)	10,859 bp
Tssr154640	Chr19:6426042-6426047 (+)	12,093 bp
Tssr154641	Chr19:6426568-6426588 (+)	12,626 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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