About   Help   FAQ
Ptch2 Gene Detail
Summary
  • Symbol
    Ptch2
  • Name
    patched 2
  • Synonyms
    ptc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095405
    NCBI Gene: 19207
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116953272-116973298 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.41 cM, cytoband C-D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    681 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095405
 protein coding gene Chr4:116953253-116973298 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028642
 protein coding gene Chr4:118053610-118075080 (+)
A/J MGP_AJ_G0028603
 protein coding gene Chr4:113502461-113526695 (+)
AKR/J MGP_AKRJ_G0028553
 protein coding gene Chr4:115980741-116003401 (+)
BALB/cJ MGP_BALBcJ_G0028624
 protein coding gene Chr4:114132891-114152740 (+)
C3H/HeJ MGP_C3HHeJ_G0028338
 protein coding gene Chr4:117548647-117570557 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029065
 protein coding gene Chr4:122606411-122626423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026349
 protein coding gene Chr4:107545643-107566731 (+)
CAST/EiJ MGP_CASTEiJ_G0027772
 protein coding gene Chr4:114766423-114788041 (+)
CBA/J MGP_CBAJ_G0028305
 protein coding gene Chr4:125953235-125975330 (+)
DBA/2J MGP_DBA2J_G0028453
 protein coding gene Chr4:114138007-114162427 (+)
FVB/NJ MGP_FVBNJ_G0028421
 protein coding gene Chr4:112640798-112660845 (+)
LP/J MGP_LPJ_G0028555
 protein coding gene Chr4:118230797-118253879 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028448
 protein coding gene Chr4:130900567-130922587 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029102
 protein coding gene Chr4:117130354-117152265 (+)
PWK/PhJ MGP_PWKPhJ_G0027498
 protein coding gene Chr4:110934000-110957472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027321
 protein coding gene Chr4:113421436-113449781 (+)
WSB/EiJ MGP_WSBEiJ_G0027851
 protein coding gene Chr4:116994705-117019663 (+)



Homology
more
  • Human Ortholog
    PTCH2, patched 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTCH2, patched 2
  • Synonyms
    PTC2
  • Links
    NCBI Gene ID: 8643
    neXtProt AC: NX_Q9Y6C5
    UniProt: Q9Y6C5

  • Chr Location
    1p34.1; chr1:44819844-44843253 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PTCH2 associations

Human Disease Mouse Models
      
IDs
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a targeted gene disruption display anemia, abnormal red blood cells, enlarged spleens, extramedullary hematopoiesis, and an increased percentage of neutrophils. Most male mice homozygous for another allele display alopecia and skin lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1137
  • Tissues
    215
  • cDNA Data
    30
  • Literature Summary
    94
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028681 Ensembl Gene Model | MGI Sequence Detail 20027 C57BL/6J ±  kb
    transcript ENSMUST00000030443 Ensembl | MGI Sequence Detail 4382 Not Applicable  
    polypeptide ENSMUSP00000030443 Ensembl | MGI Sequence Detail 1182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 30
      Primer pair 12
      Other 10

      Microarray probesets 4
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 94
      Diseases 1
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:41710 Takabatake T, et al., Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett. 1997 Jun 30;410(2-3):485-9
    • Latest
      J:353623 Almubarak A, et al., FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton. Development. 2024 Aug 15;151(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory