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Tuba3a Gene Detail
Summary
  • Symbol
    Tuba3a
  • Name
    tubulin, alpha 3A
  • Synonyms
    M[a]3, Tuba3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095406
    NCBI Gene: 22144
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125255237-125263005 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095406
 protein coding gene Chr6:125255233-125263044 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031264
 protein coding gene Chr6:123766439-123774571 (-)
AKR/J MGP_AKRJ_G0031192
 protein coding gene Chr6:127142669-127150401 (-)
BALB/cJ MGP_BALBcJ_G0031464
 protein coding gene Chr6:144423150-144424688 (+)
C3H/HeJ MGP_C3HHeJ_G0030995
 protein coding gene Chr6:127214256-127223747 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031728
 protein coding gene Chr6:132010028-132017826 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028877
 protein coding gene Chr6:120976680-120985664 (-)
CAST/EiJ MGP_CASTEiJ_G0030376
 protein coding gene Chr6:127427758-127435539 (-)
CBA/J MGP_CBAJ_G0030956
 protein coding gene Chr6:137063644-137074339 (-)
DBA/2J MGP_DBA2J_G0031112
 protein coding gene Chr6:122693122-122701178 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031192
 protein coding gene Chr6:128782914-128791809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031100
 protein coding gene Chr6:141103439-141111180 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031763
 protein coding gene Chr6:127046497-127056013 (-)
PWK/PhJ MGP_PWKPhJ_G0030091
 protein coding gene Chr6:120941210-120948996 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029920
 protein coding gene Chr6:125124468-125132214 (-)
WSB/EiJ MGP_WSBEiJ_G0030461
 protein coding gene Chr6:127420077-127427845 (-)



Homology
more
  • Human Ortholog
    TUBA3C, tubulin alpha 3c
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA3C, tubulin alpha 3c
  • Synonyms
    bA408E5.3, TUBA2
  • Links
    NCBI Gene ID: 7278
    neXtProt AC: NX_P0DPH7
    UniProt: P0DPH7

  • Chr Location
    13q12.11; chr13:19173772-19181824 (-)  GRCh38
  • Human Ortholog
    TUBA3D, tubulin alpha 3d
  • Synonyms
    H2-ALPHA, KTCN9, TUBA2
  • Links
    NCBI Gene ID: 113457
    neXtProt AC: NX_P0DPH8
    UniProt: P0DPH8

  • Chr Location
    2q21.1; chr2:131476119-131482934 (+)  GRCh38
  • Human Ortholog
    TUBA3E, tubulin alpha 3e
  • Links
    NCBI Gene ID: 112714
    neXtProt AC: NX_Q6PEY2
    UniProt: Q6PEY2

  • Chr Location
    2q21.1; chr2:130191745-130198439 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TUBA3D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal testis size and fertility. Mice homozygous for both Tuba3a and 3b exhibit small testis and postnatal depletion of germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    14
  • cDNA Data
    100
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067702 Ensembl Gene Model | MGI Sequence Detail 7769 C57BL/6J ±  kb
transcript ENSMUST00000088246 Ensembl | MGI Sequence Detail 1509 Not Applicable  
polypeptide ENSMUSP00000085580 Ensembl | MGI Sequence Detail 450 Not Applicable  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 106
    cDNA 100
    Primer pair 6

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141443
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory