Tuba4a MGI Mouse Gene Detail - MGI:1095410

Symbol

Tuba4a
Name

tubulin, alpha 4A
Synonyms

M[a]4, Tuba4

Feature Type

protein coding gene
IDs

MGI:1095410
NCBI Gene: 22145
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:75190872-75196509 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.63 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095410	protein coding gene	Chr1:75190867-75197905 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016179	protein coding gene	Chr1:75778358-75783995 (-)
A/J	MGP_AJ_G0016162	protein coding gene	Chr1:73136948-73142585 (-)
AKR/J	MGP_AKRJ_G0016119	protein coding gene	Chr1:75166118-75171755 (-)
BALB/cJ	MGP_BALBcJ_G0016117	protein coding gene	Chr1:73197913-73203550 (-)
C3H/HeJ	MGP_C3HHeJ_G0015948	protein coding gene	Chr1:75499331-75504968 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016570	protein coding gene	Chr1:78727438-78733075 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014291	protein coding gene	Chr1:68696921-68702572 (-)
CAST/EiJ	MGP_CASTEiJ_G0015532	protein coding gene	Chr1:74837232-74842870 (-)
CBA/J	MGP_CBAJ_G0015921	protein coding gene	Chr1:81287826-81293463 (-)
DBA/2J	MGP_DBA2J_G0016022	protein coding gene	Chr1:72455161-72460798 (-)
FVB/NJ	MGP_FVBNJ_G0016025	protein coding gene	Chr1:71654103-71659740 (-)
LP/J	MGP_LPJ_G0016094	protein coding gene	Chr1:76902631-76908268 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016045	protein coding gene	Chr1:84645885-84651522 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016617	protein coding gene	Chr1:75237130-75242767 (-)
PWK/PhJ	MGP_PWKPhJ_G0015319	protein coding gene	Chr1:71925452-71931099 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015097	protein coding gene	Chr1:74595225-74600859 (-)
WSB/EiJ	MGP_WSBEiJ_G0015594	protein coding gene	Chr1:75049046-75054683 (-)

Human Ortholog

TUBA4A, tubulin alpha 4a

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TUBA4A, tubulin alpha 4a
Synonyms

ALS22, H2-ALPHA, TUBA1
Links

HGNC:12407

NCBI Gene ID: 7277

neXtProt AC: NX_P68366

UniProt: P68366
Chr Location

2q35; chr2:219249710-219277902 (-) GRCh38

MGI Vertebrate Homology

Tuba4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TUBA4A
Gene Tree

Tuba4a

Diseases

1 with human TUBA4A associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis type 22 IDs amyotrophic lateral sclerosis type 22 DOID:0060355 OMIM:616208

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

7
Radiation induced

2
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Tuba4a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Homozygous knockout results in a low platelet count and spherical platelets.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

27
cDNA Data

8
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tuba4b

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All Sequences

66
RefSeq

14
UniProt

7
CCDS

CCDS35623.1

Ensembl

ENSMUSG00000026202 (Evidence)
NCBI Gene

22145

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026202	Ensembl Gene Model \| MGI Sequence Detail	5638	C57BL/6J	± kb
transcript	ENSMUST00000079464	Ensembl \| MGI Sequence Detail	2083	Not Applicable
polypeptide	ENSMUSP00000078429	Ensembl \| MGI Sequence Detail	477	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016812 tubulin alpha-4A chain

(term hierarchy)
PDB

8IXF, 8IXG
EC

3.6.5.-
InterPro Domains

IPR002452 Alpha tubulin

IPR000217 Tubulin

IPR017975 Tubulin, conserved site

IPR023123 Tubulin, C-terminal

IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

IPR008280 Tubulin/FtsZ, C-terminal

IPR003008 Tubulin/FtsZ, GTPase domain

IPR036525 Tubulin/FtsZ, GTPase domain superfamily

IPR037103 Tubulin/FtsZ-like, C-terminal domain
GlyGen

P68368 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 5

Summaries

All 66

Developmental Gene Expression 13

Diseases 1

Gene Ontology 7

Phenotypes 26
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531

TSS for Tuba4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12376	Chr1:75196555-75196566 (-)	-52 bp
Tssr12375	Chr1:75196497-75196535 (-)	-7 bp
Tssr12374	Chr1:75195889-75195906 (-)	611 bp
Tssr12373	Chr1:75195127-75195138 (-)	1,376 bp
Tssr12372	Chr1:75193938-75193948 (-)	2,566 bp
Tssr12371	Chr1:75193593-75193615 (-)	2,905 bp
Tssr12370	Chr1:75193160-75193190 (-)	3,334 bp
Tssr12369	Chr1:75193082-75193094 (-)	3,421 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24