Unc5c MGI Mouse Gene Detail - MGI:1095412

Symbol

Unc5c
Name

unc-5 netrin receptor C
Synonyms

B130051O18Rik, Unc5h3

Feature Type

protein coding gene
IDs

MGI:1095412
NCBI Gene: 22253
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr3:141171360-141540685 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 65.57 cM
Mapping Data

6 experiments

SNPs within 2kb

10488 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095412	protein coding gene	Chr3:141170977-141540685 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027938	protein coding gene	Chr3:144616922-144984695 (+)
A/J	MGP_AJ_G0027895	protein coding gene	Chr3:139499204-139863732 (+)
AKR/J	MGP_AKRJ_G0027861	protein coding gene	Chr3:143187683-143554073 (+)
BALB/cJ	MGP_BALBcJ_G0027907	protein coding gene	Chr3:139297886-139668601 (+)
C3H/HeJ	MGP_C3HHeJ_G0027637	protein coding gene	Chr3:143531117-143909925 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028351	protein coding gene	Chr3:149676259-150054134 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025689	protein coding gene	Chr3:134747385-135099287 (+)
CAST/EiJ	MGP_CASTEiJ_G0027093	protein coding gene	Chr3:143415607-143800388 (+)
CBA/J	MGP_CBAJ_G0027614	protein coding gene	Chr3:154803155-155199775 (+)
DBA/2J	MGP_DBA2J_G0027753	protein coding gene	Chr3:138605987-138963336 (+)
FVB/NJ	MGP_FVBNJ_G0027720	protein coding gene	Chr3:136055446-136415291 (+)
LP/J	MGP_LPJ_G0027863	protein coding gene	Chr3:146062671-146437937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027752	protein coding gene	Chr3:163111584-163523434 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028409	protein coding gene	Chr3:142797304-143162832 (+)
PWK/PhJ	MGP_PWKPhJ_G0026817	protein coding gene	Chr3:138415443-138779058 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026644	protein coding gene	Chr3:140879152-141250447 (+)
WSB/EiJ	MGP_WSBEiJ_G0027172	protein coding gene	Chr3:143660675-144032342 (+)

Human Ortholog

UNC5C, unc-5 netrin receptor C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC5C, unc-5 netrin receptor C
Synonyms

UNC5H3
Links

HGNC:12569

NCBI Gene ID: 8633

neXtProt AC: NX_O95185

UniProt: O95185
Chr Location

4q22.3; chr4:95162504-95549206 (-) GRCh38

MGI Vertebrate Homology

Unc5c stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UNC5C
Gene Tree

Unc5c

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References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 3 alleles in 4 genetic backgrounds
28 phenotypes from multigenic genotypes
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

6
Radiation induced

1
Spontaneous

1
Targeted

4
Transgenic

2
Genomic Mutations

2 involving Unc5c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutants exhibit ataxia, and reduced size early in life. Mutants exhibit cerebellar defects including reduced size and ectopic cerebellar cells in the midbrain.

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All GO Annotations

38
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1208
Tissues

226
cDNA Data

55
Literature Summary

63

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA UNC5C

ZFIN unc5cb

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All Sequences

57
RefSeq

4
UniProt

7
CCDS

CCDS17873.1, CCDS80034.1

Ensembl

ENSMUSG00000059921 (Evidence)
NCBI Gene

22253

			Length	Strain/Species	Flank
genomic	22253	NCBI Gene Model \| MGI Sequence Detail	369326	C57BL/6J	± kb
transcript	NM_001293561	RefSeq \| MGI Sequence Detail	9320	ZRU/MplStud
polypeptide	O08747	UniProt \| EBI \| MGI Sequence Detail	931	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017095 netrin receptor UNC5C

(term hierarchy)
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR037936 Netrin receptor UNC5

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR042154 UNC5C, death domain

IPR033772 UPA domain

IPR000906 ZU5 domain
GlyGen

O08747 2 sites

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All nucleic 74

Genomic 1

cDNA 59

Primer pair 10

Other 4

Microarray probesets 4

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MGD-MRK-13803, MGI:2139620, MGI:2442491, MGI:97881

Summaries

All 124

Developmental Gene Expression 63

Diseases 1

Gene Ontology 16

Phenotypes 43
Earliest

J:28673 Boyer BB, et al., The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol Cell Biol. 1991 Aug;11(8):4147-56
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Unc5c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1065	Chr3:141170456-141170463 (+)	-900 bp
Tssr32031	Chr3:141170877-141170890 (+)	-476 bp
Tssr32032	Chr3:141170940-141170984 (+)	-398 bp
Tssr1066	Chr3:141171022-141171030 (+)	-334 bp
Tssr32033	Chr3:141171132-141171142 (+)	-223 bp
Tssr32034	Chr3:141171247-141171252 (+)	-110 bp
Tssr32035	Chr3:141171303-141171310 (+)	-53 bp
Tssr32036	Chr3:141171328-141171331 (+)	-30 bp
Tssr32037	Chr3:141171353-141171372 (+)	3 bp
Tssr1067	Chr3:141171415-141171425 (+)	60 bp
Tssr32038	Chr3:141197295-141197299 (+)	25,937 bp
Tssr32039	Chr3:141215882-141215894 (+)	44,528 bp
Tssr32040	Chr3:141233460-141233463 (+)	62,102 bp
Tssr32041	Chr3:141237621-141237638 (+)	66,270 bp
Tssr32042	Chr3:141297825-141297829 (+)	126,467 bp
Tssr32043	Chr3:141321015-141321020 (+)	149,658 bp
Tssr32044	Chr3:141337725-141337733 (+)	166,369 bp
Tssr32045	Chr3:141340322-141340363 (+)	168,983 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24