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Lfng Gene Detail
Summary
  • Symbol
    Lfng
  • Name
    LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Synonyms
    lunatic fringe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095413
    NCBI Gene: 16848
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140593096-140601300 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 79.15 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095413
 protein coding gene Chr5:140593075-140601300 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030302
 protein coding gene Chr5:145712191-145721922 (+)
A/J MGP_AJ_G0030271
 protein coding gene Chr5:139488509-139498407 (+)
AKR/J MGP_AKRJ_G0030203
 protein coding gene Chr5:143847452-143855691 (+)
BALB/cJ MGP_BALBcJ_G0030288
 protein coding gene Chr5:140737034-140745237 (+)
C3H/HeJ MGP_C3HHeJ_G0029999
 protein coding gene Chr5:144647393-144657135 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030733
 protein coding gene Chr5:151103592-151112427 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027951
 protein coding gene Chr5:133324155-133332443 (+)
CAST/EiJ MGP_CASTEiJ_G0029404
 protein coding gene Chr5:144068805-144078144 (+)
CBA/J MGP_CBAJ_G0029969
 protein coding gene Chr5:157296385-157304636 (+)
DBA/2J MGP_DBA2J_G0030119
 protein coding gene Chr5:139302930-139311159 (+)
FVB/NJ MGP_FVBNJ_G0030074
 protein coding gene Chr5:138457745-138466205 (+)
LP/J MGP_LPJ_G0030205
 protein coding gene Chr5:146320558-146328783 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030105
 protein coding gene Chr5:159895397-159903616 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030773
 protein coding gene Chr5:143688636-143696848 (+)
PWK/PhJ MGP_PWKPhJ_G0029119
 protein coding gene Chr5:138324388-138332791 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028955
 protein coding gene Chr5:141395548-141403804 (+)
WSB/EiJ MGP_WSBEiJ_G0029478
 protein coding gene Chr5:144472790-144481059 (+)



Homology
more
  • Human Ortholog
    LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Synonyms
    SCDO3
  • Links
    NCBI Gene ID: 3955
    neXtProt AC: NX_Q8NES3
    UniProt: Q8NES3

  • Chr Location
    7p22.3; chr7:2512529-2529177 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LFNG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 6 alleles in 13 genetic backgrounds
    33 phenotypes from multigenic genotypes
    4 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a short tail and abnormal rib, somite, and lung development. Mice homozygous mice exhibit reduced female fertility, abnormal hair cells, and abnormal axial skeleton morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1293
  • Tissues
    174
  • cDNA Data
    61
  • Literature Summary
    219
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16848 NCBI Gene Model | MGI Sequence Detail 8205 C57BL/6J ±  kb
    transcript NM_008494 RefSeq | MGI Sequence Detail 2299 C57BL/6  
    polypeptide O09010 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 66
      Primer pair 7
      Other 38

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141150
    References
    more
    • Summaries
      All 283
      Developmental Gene Expression 219
      Gene Ontology 13
      Phenotypes 53
    • Earliest
      J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
    • Latest
      J:357898 Feng X, et al., Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2310283121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory