Cdh17 MGI Mouse Gene Detail - MGI:1095414

Symbol

Cdh17
Name

cadherin 17
Synonyms

BILL-cadherin, HPT-1, LI-cadherin

Feature Type

protein coding gene
IDs

MGI:1095414
NCBI Gene: 12557
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:11758157-11817905 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 5.35 cM, cytoband A2
Mapping Data

1 experiment

SNPs within 2kb

1644 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095414	protein coding gene	Chr4:11758147-11817905 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028057	protein coding gene	Chr4:8442009-8508009 (+)
A/J	MGP_AJ_G0028014	protein coding gene	Chr4:8310992-8366030 (+)
AKR/J	MGP_AKRJ_G0027980	protein coding gene	Chr4:8403365-8463023 (+)
BALB/cJ	MGP_BALBcJ_G0028026	protein coding gene	Chr4:8230771-8292241 (+)
C3H/HeJ	MGP_C3HHeJ_G0027756	protein coding gene	Chr4:8576904-8635036 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028470	protein coding gene	Chr4:8860265-8922039 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025813	protein coding gene	Chr4:7824019-7886531 (+)
CAST/EiJ	MGP_CASTEiJ_G0027210	protein coding gene	Chr4:8394039-8462047 (+)
CBA/J	MGP_CBAJ_G0027731	protein coding gene	Chr4:9115115-9177088 (+)
DBA/2J	MGP_DBA2J_G0027872	protein coding gene	Chr4:8175229-8234176 (+)
FVB/NJ	MGP_FVBNJ_G0027838	protein coding gene	Chr4:7996744-8057304 (+)
LP/J	MGP_LPJ_G0027982	protein coding gene	Chr4:8523909-8588485 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027871	protein coding gene	Chr4:9293350-9354614 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028528	protein coding gene	Chr4:8400750-8462192 (+)
PWK/PhJ	MGP_PWKPhJ_G0026931	protein coding gene	Chr4:8189658-8254304 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026761	protein coding gene	Chr4:8318404-8379120 (+)
WSB/EiJ	MGP_WSBEiJ_G0027289	protein coding gene	Chr4:8464981-8531338 (+)

Human Ortholog

CDH17, cadherin 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDH17, cadherin 17
Synonyms

CDH16, HPT-1, HPT1
Links

HGNC:1756

NCBI Gene ID: 1015

neXtProt AC: NX_Q12864

UniProt: Q12864
Chr Location

8q22.1; chr8:94127162-94217303 (-) GRCh38

MGI Vertebrate Homology

Cdh17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDH17
Gene Tree

Cdh17

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

1
Spontaneous

1
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Cdh17
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibit impaired B lymphocyte development and impaired IgG1 and IgG3 antibody response to T-independent antigen.

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All GO Annotations

38
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

62
cDNA Data

17
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDH17

Xenbase cdh17

ZFIN cdh17

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All Sequences

42
RefSeq

6
UniProt

4
CCDS

CCDS17972.1

Ensembl

ENSMUSG00000028217 (Evidence)
NCBI Gene

12557

			Length	Strain/Species	Flank
genomic	12557	NCBI Gene Model \| MGI Sequence Detail	59749	C57BL/6J	± kb
transcript	NM_019753	RefSeq \| MGI Sequence Detail	3475	C57BL/6
polypeptide	Q9R100	UniProt \| EBI \| MGI Sequence Detail	827	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005235 cadherin-17

(term hierarchy)
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily
GlyGen

Q9R100 7 sites, 1 N-linked glycan (1 site)

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 4

Diseases 1

Gene Ontology 11

Phenotypes 13
Earliest

J:33453 Dantzig AH, et al., Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science. 1994 Apr 15;264(5157):430-3
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931

TSS for Cdh17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36494	Chr4:11758174-11758220 (+)	40 bp
Tssr36495	Chr4:11758224-11758234 (+)	72 bp
Tssr36496	Chr4:11761010-11761013 (+)	2,855 bp
Tssr36497	Chr4:11765268-11765285 (+)	7,120 bp
Tssr36498	Chr4:11810283-11810305 (+)	52,137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24