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Ptprr Gene Detail
Summary
  • Symbol
    Ptprr
  • Name
    protein tyrosine phosphatase receptor type R
  • Synonyms
    PTPBR7, PTP-SL, RPTPRR
  • Feature Type
    protein coding gene
  • IDs
    MGI:109559
    NCBI Gene: 19279
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:115854118-116110837 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 64.01 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7517 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109559
 protein coding gene Chr10:115854093-116110837 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017742
 protein coding gene Chr10:118766908-119034520 (+)
A/J MGP_AJ_G0017718
 protein coding gene Chr10:114208423-114462338 (+)
AKR/J MGP_AKRJ_G0017680
 protein coding gene Chr10:117501343-117760840 (+)
BALB/cJ MGP_BALBcJ_G0017681
 protein coding gene Chr10:114607663-114860909 (+)
C3H/HeJ MGP_C3HHeJ_G0017506
 protein coding gene Chr10:117740190-118001939 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018138
 protein coding gene Chr10:122910088-123172875 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015818
 protein coding gene Chr10:108817882-109066494 (+)
CAST/EiJ MGP_CASTEiJ_G0017068
 protein coding gene Chr10:118002702-118278923 (+)
CBA/J MGP_CBAJ_G0017475
 protein coding gene Chr10:127703130-127986133 (+)
DBA/2J MGP_DBA2J_G0017580
 protein coding gene Chr10:113351078-113605636 (+)
FVB/NJ MGP_FVBNJ_G0017575
 protein coding gene Chr10:112297711-112561537 (+)
LP/J MGP_LPJ_G0017655
 protein coding gene Chr10:119348103-119622991 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017604
 protein coding gene Chr10:130626152-130901302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018176
 protein coding gene Chr10:117574718-117839360 (+)
PWK/PhJ MGP_PWKPhJ_G0016850
 protein coding gene Chr10:113440458-113685396 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016640
 protein coding gene Chr10:116365898-116643447 (+)
WSB/EiJ MGP_WSBEiJ_G0017128
 protein coding gene Chr10:117759751-118016600 (+)



Homology
more
  • Human Ortholog
    PTPRR, protein tyrosine phosphatase receptor type R
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRR, protein tyrosine phosphatase receptor type R
  • Synonyms
    EC-PTP, PCPTP1, PTPBR7, PTPRQ, PTP-SL
  • Links
    NCBI Gene ID: 5801
    neXtProt AC: NX_Q15256
    UniProt: Q15256

  • Chr Location
    12q15; chr12:70638073-70920738 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased ERK1/2 phosphorylation levels in cerebellar Purkinje cells, decreased grip strength, and ataxia characterized by fine motor coordination and balance defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    27
  • cDNA Data
    22
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020151 Ensembl Gene Model | MGI Sequence Detail 256720 C57BL/6J ±  kb
transcript ENSMUST00000063470 Ensembl | MGI Sequence Detail 3619 Not Applicable  
polypeptide ENSMUSP00000064392 Ensembl | MGI Sequence Detail 656 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013478 receptor-type tyrosine-protein phosphatase R
    (term hierarchy)
  • PDB
    1JLN
  • EC
    3.1.3.48
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR008356 Protein-tyrosine phosphatase, KIM-containing
    IPR029021 Protein-tyrosine phosphatase-like
    IPR016334 Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
    IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
    IPR000387 Tyrosine-specific protein phosphatases domain
  • GlyGen
    Q62132 3 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 24
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-39558
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:212986 Erkens M, et al., Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory. Behav Brain Res. 2014 May 15;265:111-20
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory