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Cxcr4 Gene Detail
Summary
  • Symbol
    Cxcr4
  • Name
    C-X-C motif chemokine receptor 4
  • Synonyms
    b2b220Clo, CD184, Cmkar4, fusin, PB-CKR, Sdf1r
  • Feature Type
    protein coding gene
  • IDs
    MGI:109563
    NCBI Gene: 12767
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:128515936-128520030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.43 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109563
 protein coding gene Chr1:128515936-128520036 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016431
 protein coding gene Chr1:131858781-131862854 (-)
A/J MGP_AJ_G0016414
 protein coding gene Chr1:126926926-126931011 (-)
AKR/J MGP_AKRJ_G0016379
 protein coding gene Chr1:130699898-130703895 (-)
BALB/cJ MGP_BALBcJ_G0016374
 protein coding gene Chr1:127305206-127309275 (-)
C3H/HeJ MGP_C3HHeJ_G0016200
 protein coding gene Chr1:130839338-130843415 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016835
 protein coding gene Chr1:136797810-136804418 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014549
 protein coding gene Chr1:120266410-120270450 (-)
CAST/EiJ MGP_CASTEiJ_G0015781
 protein coding gene Chr1:129837452-129843088 (-)
CBA/J MGP_CBAJ_G0016173
 protein coding gene Chr1:141405834-141409740 (-)
DBA/2J MGP_DBA2J_G0016279
 protein coding gene Chr1:125973776-125977853 (-)
FVB/NJ MGP_FVBNJ_G0016278
 protein coding gene Chr1:124674263-124678596 (-)
LP/J MGP_LPJ_G0016350
 protein coding gene Chr1:133204362-133209280 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016303
 protein coding gene Chr1:147236990-147241764 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016871
 protein coding gene Chr1:130474754-130478868 (-)
PWK/PhJ MGP_PWKPhJ_G0015567
 protein coding gene Chr1:124945341-124949629 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015355
 protein coding gene Chr1:129408913-129412973 (-)
WSB/EiJ MGP_WSBEiJ_G0015843
 protein coding gene Chr1:130419562-130424971 (-)



Homology
more
  • Human Ortholog
    CXCR4, C-X-C motif chemokine receptor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCR4, C-X-C motif chemokine receptor 4
  • Synonyms
    CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, WHIMS1
  • Links
    NCBI Gene ID: 7852
    neXtProt AC: NX_P61073
    UniProt: P61073

  • Chr Location
    2q22.1; chr2:136114349-136119177 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Cxcr4 mouse models; 10 with human CXCR4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    146 phenotypes from 10 alleles in 12 genetic backgrounds
    8 phenotypes from multigenic genotypes
    29 images
    221 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants exhibit altered viability, lungs, kidneys, immune system, hematopoiesis, myelopoiesis, cerebellar foliation, neuronal cell layer development, susceptibility to diet-induced obesity and adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1161
  • Tissues
    238
  • cDNA Data
    62
  • Literature Summary
    148
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045382 Ensembl Gene Model | MGI Sequence Detail 4095 C57BL/6J ±  kb
    transcript ENSMUST00000052172 Ensembl | MGI Sequence Detail 1805 Not Applicable  
    polypeptide ENSMUSP00000053489 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      Genomic 2
      cDNA 64
      Primer pair 12
      Other 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39562, MGI:5311025
    References
    more
    • Summaries
      All 503
      Developmental Gene Expression 148
      Diseases 2
      Gene Ontology 29
      Phenotypes 221
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358306 Asbelaoui N, et al., Interplay between androgen and CXCR4 chemokine signaling in myelin repair. Acta Neuropathol Commun. 2024 Jan 30;12(1):18
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory