Tectb MGI Mouse Gene Detail - MGI:109574

Symbol

Tectb
Name

tectorin beta
Synonyms

[b]-tectorin, Tctnb

Feature Type

protein coding gene
IDs

MGI:109574
NCBI Gene: 21684
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:55169165-55184745 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 51.13 cM
Mapping Data

4 experiments

SNPs within 2kb

639 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109574	protein coding gene	Chr19:55169158-55184745 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025255	protein coding gene	Chr19:55443865-55459485 (+)
A/J	MGP_AJ_G0025231	protein coding gene	Chr19:52719459-52735038 (+)
AKR/J	MGP_AKRJ_G0025200	protein coding gene	Chr19:54377655-54396637 (+)
BALB/cJ	MGP_BALBcJ_G0025226	protein coding gene	Chr19:52789242-52804838 (+)
C3H/HeJ	MGP_C3HHeJ_G0024986	protein coding gene	Chr19:54606412-54621979 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025669	protein coding gene	Chr19:56811997-56830052 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023081	protein coding gene	Chr19:51649236-51665528 (+)
CAST/EiJ	MGP_CASTEiJ_G0024451	protein coding gene	Chr19:54598576-54613984 (+)
CBA/J	MGP_CBAJ_G0024966	protein coding gene	Chr19:59605558-59621121 (+)
DBA/2J	MGP_DBA2J_G0025098	protein coding gene	Chr19:52515121-52530717 (+)
FVB/NJ	MGP_FVBNJ_G0025059	protein coding gene	Chr19:52217909-52233478 (+)
LP/J	MGP_LPJ_G0025184	protein coding gene	Chr19:55319121-55334669 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025092	protein coding gene	Chr19:58981687-58997232 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025727	protein coding gene	Chr19:54586684-54602250 (+)
PWK/PhJ	MGP_PWKPhJ_G0024199	protein coding gene	Chr19:52442164-52457848 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024002	protein coding gene	Chr19:53260599-53276046 (+)
WSB/EiJ	MGP_WSBEiJ_G0024521	protein coding gene	Chr19:54710362-54725966 (+)

Human Ortholog

TECTB, tectorin beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TECTB, tectorin beta
Links

HGNC:11721

NCBI Gene ID: 6975

neXtProt AC: NX_Q96PL2

UniProt: Q96PL2
Chr Location

10q25.2; chr10:112283400-112305038 (+) GRCh38

MGI Vertebrate Homology

Tectb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TECTB
Gene Tree

Tectb

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show an enlarged tectorial membrane with a disrupted striated-sheet matrix, absence of the marginal band, and low-frequency hearing loss. However, basilar-membrane and neural tuning are both enhanced in high-frequency cochlear regions, with little loss in sensitivity.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

26
cDNA Data

15
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TECTB

Xenbase tectb

ZFIN tectb

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All Sequences

45
RefSeq

6
UniProt

5
CCDS

CCDS29907.1

Ensembl

ENSMUSG00000024979 (Evidence)
NCBI Gene

21684

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024979	Ensembl Gene Model \| MGI Sequence Detail	15581	C57BL/6J	± kb
transcript	ENSMUST00000120936	Ensembl \| MGI Sequence Detail	1349	Not Applicable
polypeptide	ENSMUSP00000113805	Ensembl \| MGI Sequence Detail	339	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016223 beta-tectorin

(term hierarchy)
InterPro Domains

IPR001507 Zona pellucida domain

IPR048290 Zona pellucida domain, chordate-type

IPR017977 Zona pellucida domain, conserved site

IPR042235 Zona pellucida, ZP-C domain
GlyGen

O08524 4 sites

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All nucleic 19

Genomic 1

cDNA 16

Primer pair 2

Microarray probesets 3

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MGD-MRK-39573

Summaries

All 52

Developmental Gene Expression 17

Gene Ontology 6

Phenotypes 6
Earliest

J:39295 Legan PK, et al., The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. J Biol Chem. 1997 Mar 28;272(13):8791-801
Latest

J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120

TSS for Tectb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157063	Chr19:55169148-55169165 (+)	-8 bp
Tssr157064	Chr19:55169231-55169241 (+)	71 bp
Tssr157065	Chr19:55170315-55170326 (+)	1,156 bp
Tssr5555	Chr19:55172086-55172117 (+)	2,937 bp
Tssr157066	Chr19:55184311-55184336 (+)	15,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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