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Tecta Gene Detail
Summary
  • Symbol
    Tecta
  • Name
    tectorin alpha
  • Synonyms
    [a]-tectorin, Tctna
  • Feature Type
    protein coding gene
  • IDs
    MGI:109575
    NCBI Gene: 21683
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:42240915-42311225 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 23.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1944 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109575
 protein coding gene Chr9:42240915-42312986 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034677
 protein coding gene Chr9:40671980-40745841 (-)
A/J MGP_AJ_G0034657
 protein coding gene Chr9:39591282-39661281 (-)
AKR/J MGP_AKRJ_G0034583
 protein coding gene Chr9:40359859-40433754 (-)
BALB/cJ MGP_BALBcJ_G0034648
 protein coding gene Chr9:39321003-39392471 (-)
C3H/HeJ MGP_C3HHeJ_G0034359
 protein coding gene Chr9:40855747-40928091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035171
 protein coding gene Chr9:41939738-42009961 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032084
 protein coding gene Chr9:39203008-39273631 (-)
CAST/EiJ MGP_CASTEiJ_G0033682
 protein coding gene Chr9:40656102-40731540 (-)
CBA/J MGP_CBAJ_G0034332
 protein coding gene Chr9:43423449-43498314 (-)
DBA/2J MGP_DBA2J_G0034491
 protein coding gene Chr9:39509874-39580270 (-)
FVB/NJ MGP_FVBNJ_G0034431
 protein coding gene Chr9:38739429-38809947 (-)
LP/J MGP_LPJ_G0034572
 protein coding gene Chr9:40948088-41022817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034475
 protein coding gene Chr9:45394215-45466052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035190
 protein coding gene Chr9:40270367-40341052 (-)
PWK/PhJ MGP_PWKPhJ_G0033387
 protein coding gene Chr9:39339817-39410738 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033223
 protein coding gene Chr9:40532732-40603904 (-)
WSB/EiJ MGP_WSBEiJ_G0033795
 protein coding gene Chr9:40307654-40379343 (-)



Homology
more
  • Human Ortholog
    TECTA, tectorin alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TECTA, tectorin alpha
  • Synonyms
    DFNA12, DFNA8, DFNB21
  • Links
    NCBI Gene ID: 7007
    neXtProt AC: NX_O75443
    UniProt: O75443

  • Chr Location
    11q23.3; chr11:121101243-121191490 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tecta mouse models; 3 with human TECTA associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 6 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a tectorial membrane that is detached from the cochlear epithelium. Though the basilar membranes of mutant mice are tuned, sensitivity is attenuated. Mice with an Y1870C mutation have a disrupted tectorial membrane, elevated neural thresholds and broadened neural tuning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    28
  • cDNA Data
    8
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037705 Ensembl Gene Model | MGI Sequence Detail 70311 C57BL/6J ±  kb
    transcript ENSMUST00000042190 Ensembl | MGI Sequence Detail 7338 Not Applicable  
    polypeptide ENSMUSP00000040262 Ensembl | MGI Sequence Detail 2155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 8
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39574
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:39295 Legan PK, et al., The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. J Biol Chem. 1997 Mar 28;272(13):8791-801
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory