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Tnfrsf11b Gene Detail
Summary
  • Symbol
    Tnfrsf11b
  • Name
    tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • Synonyms
    OCIF, Opg, OPG, osteoclastogenesis inhibitory factor, TR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109587
    NCBI Gene: 18383
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54114014-54141700 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    924 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109587
 protein coding gene Chr15:54114014-54141880 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021846
 protein coding gene Chr15:53291391-53323857 (-)
A/J MGP_AJ_G0021806
 protein coding gene Chr15:51175610-51203457 (-)
AKR/J MGP_AKRJ_G0021787
 protein coding gene Chr15:52618733-52646595 (-)
BALB/cJ MGP_BALBcJ_G0021813
 protein coding gene Chr15:51402513-51430364 (-)
C3H/HeJ MGP_C3HHeJ_G0021587
 protein coding gene Chr15:52713001-52740871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022252
 protein coding gene Chr15:55377557-55406206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019789
 protein coding gene Chr15:48454156-48482076 (-)
CAST/EiJ MGP_CASTEiJ_G0021104
 protein coding gene Chr15:53278640-53307077 (-)
CBA/J MGP_CBAJ_G0021556
 protein coding gene Chr15:57348446-57377768 (-)
DBA/2J MGP_DBA2J_G0021680
 protein coding gene Chr15:51064441-51092124 (-)
FVB/NJ MGP_FVBNJ_G0021658
 protein coding gene Chr15:50213674-50241470 (-)
LP/J MGP_LPJ_G0021750
 protein coding gene Chr15:53100485-53128126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021682
 protein coding gene Chr15:62409668-62440678 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022275
 protein coding gene Chr15:52966374-52994226 (-)
PWK/PhJ MGP_PWKPhJ_G0020849
 protein coding gene Chr15:51135535-51163779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020686
 protein coding gene Chr15:52707516-52734766 (-)
WSB/EiJ MGP_WSBEiJ_G0021159
 protein coding gene Chr15:52956537-52987377 (-)



Homology
more
  • Human Ortholog
    TNFRSF11B, TNF receptor superfamily member 11b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF11B, TNF receptor superfamily member 11b
  • Synonyms
    OCIF, OPG, PDB5, TR1
  • Links
    NCBI Gene ID: 4982
    neXtProt AC: NX_O00300
    UniProt: O00300

  • Chr Location
    8q24.12; chr8:118923557-118951885 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfrsf11b mouse models; 3 with human TNFRSF11B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 4 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation. Progressive hearing loss also results due to abnormal remodeling of the otic capsule.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    55
  • cDNA Data
    30
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18383 NCBI Gene Model | MGI Sequence Detail 27687 C57BL/6J ±  kb
    transcript NM_001411506 RefSeq | MGI Sequence Detail 2756 C57BL/6  
    polypeptide O08712 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 30
      Primer pair 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39586
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 42
      Diseases 2
      Gene Ontology 14
      Phenotypes 83
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:357895 Houchen CJ, et al., TGF-beta signaling in the cranial neural crest affects late-stage mandibular bone resorption and length. Front Physiol. 2024;15:1435594
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory