Cmklr1 MGI Mouse Gene Detail - MGI:109603 - chemerin chemokine-like receptor 1

Symbol

Cmklr1
Name

chemerin chemokine-like receptor 1
Synonyms

ChemR23, Gpcr27

Feature Type

protein coding gene
IDs

MGI:109603
NCBI Gene: 14747
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:113750415-113788487 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.55 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

1090 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109603	protein coding gene	Chr5:113750415-113792971 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029919	protein coding gene	Chr5:116281724-116321945 (-)
A/J	MGP_AJ_G0029884	protein coding gene	Chr5:111727556-111765573 (-)
AKR/J	MGP_AKRJ_G0029822	protein coding gene	Chr5:115267633-115307369 (-)
BALB/cJ	MGP_BALBcJ_G0029895	protein coding gene	Chr5:113092856-113130885 (-)
C3H/HeJ	MGP_C3HHeJ_G0029615	protein coding gene	Chr5:115741628-115780776 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030349	protein coding gene	Chr5:120803936-120842806 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027577	protein coding gene	Chr5:106553796-106592880 (-)
CAST/EiJ	MGP_CASTEiJ_G0029023	protein coding gene	Chr5:114678462-114716305 (-)
CBA/J	MGP_CBAJ_G0029582	protein coding gene	Chr5:125367103-125404874 (-)
DBA/2J	MGP_DBA2J_G0029732	protein coding gene	Chr5:111794597-111832575 (-)
FVB/NJ	MGP_FVBNJ_G0029689	protein coding gene	Chr5:110561917-110602482 (-)
LP/J	MGP_LPJ_G0029821	protein coding gene	Chr5:116846042-116885487 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029720	protein coding gene	Chr5:129861267-129900322 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030390	protein coding gene	Chr5:114723144-114761167 (-)
PWK/PhJ	MGP_PWKPhJ_G0028737	protein coding gene	Chr5:110419099-110457941 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028575	protein coding gene	Chr5:112247920-112286772 (-)
WSB/EiJ	MGP_WSBEiJ_G0029099	protein coding gene	Chr5:115273145-115315039 (-)

Human Ortholog

CMKLR1, chemerin chemokine-like receptor 1

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CMKLR1, chemerin chemokine-like receptor 1
Synonyms

CHEMERINR, ChemR23, DEZ, ERV1, RVER1
Links

HGNC:2121

NCBI Gene ID: 1240

neXtProt AC: NX_Q99788

UniProt: Q99788
Chr Location

12q23.3; chr12:108288044-108339317 (-) GRCh38

MGI Vertebrate Homology

Cmklr1 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: CMKLR1
Gene Tree

Cmklr1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

11
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cmklr1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have defects in immunomodulation of monocyte and neutriphils by chemerin

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

87
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cmklr1

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All Sequences

48
RefSeq

12
UniProt

4
CCDS

CCDS19551.1

Ensembl

ENSMUSG00000042190 (Evidence)
NCBI Gene

14747

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042190	Ensembl Gene Model \| MGI Sequence Detail	38073	C57BL/6J	± kb
transcript	ENSMUST00000047936	Ensembl \| MGI Sequence Detail	2882	Not Applicable
polypeptide	ENSMUSP00000036316	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001129 chemokine receptor-like protein CMKLR1

(term hierarchy)
InterPro Domains

IPR002258 Chemerin-like receptor 1

IPR000826 Formyl peptide receptor-related

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P97468 2 sites

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All nucleic 15

cDNA 15

Microarray probesets 3

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MGD-MRK-39602

Summaries

All 83

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 40
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:352306 Johnston RA, et al., Inconsequential role for chemerin-like receptor 1 in the manifestation of ozone-induced lung pathophysiology in male mice. Physiol Rep. 2024 Apr;12(8):e16008

TSS for Cmklr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52647	Chr5:113788630-113788641 (-)	-149 bp
Tssr52646	Chr5:113788451-113788509 (-)	7 bp
Tssr52645	Chr5:113788432-113788442 (-)	50 bp
Tssr52644	Chr5:113782320-113782342 (-)	6,156 bp
Tssr52643	Chr5:113777262-113777266 (-)	11,223 bp
Tssr52642	Chr5:113752395-113752420 (-)	36,079 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24