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Plk3 Gene Detail
Summary
  • Symbol
    Plk3
  • Name
    polo like kinase 3
  • Synonyms
    Cnk
  • Feature Type
    protein coding gene
  • IDs
    MGI:109604
    NCBI Gene: 12795
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116985852-116991160 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.41 cM
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109604
 protein coding gene Chr4:116985852-116991244 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028645
 protein coding gene Chr4:118087716-118093013 (-)
A/J MGP_AJ_G0028606
 protein coding gene Chr4:113539692-113544989 (-)
AKR/J MGP_AKRJ_G0028556
 protein coding gene Chr4:116017483-116022781 (-)
BALB/cJ MGP_BALBcJ_G0028627
 protein coding gene Chr4:114166677-114171982 (-)
C3H/HeJ MGP_C3HHeJ_G0028341
 protein coding gene Chr4:117584512-117589817 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029068
 protein coding gene Chr4:122639967-122645264 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026352
 protein coding gene Chr4:107580069-107585384 (-)
CAST/EiJ MGP_CASTEiJ_G0027775
 protein coding gene Chr4:114800394-114805699 (-)
CBA/J MGP_CBAJ_G0028308
 protein coding gene Chr4:125993795-125999100 (-)
DBA/2J MGP_DBA2J_G0028456
 protein coding gene Chr4:114174978-114180275 (-)
FVB/NJ MGP_FVBNJ_G0028424
 protein coding gene Chr4:112674415-112679719 (-)
LP/J MGP_LPJ_G0028558
 protein coding gene Chr4:118266429-118271726 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028451
 protein coding gene Chr4:130936476-130941774 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029105
 protein coding gene Chr4:117164825-117170123 (-)
PWK/PhJ MGP_PWKPhJ_G0027501
 protein coding gene Chr4:110970234-110975540 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027324
 protein coding gene Chr4:113462599-113469115 (-)
WSB/EiJ MGP_WSBEiJ_G0027854
 protein coding gene Chr4:117033527-117038816 (-)



Homology
more
  • Human Ortholog
    PLK3, polo like kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLK3, polo like kinase 3
  • Synonyms
    CNK, FNK, PLK-3, PRK
  • Links
    NCBI Gene ID: 1263
    neXtProt AC: NX_Q9H4B4
    UniProt: Q9H4B4

  • Chr Location
    1p34.1; chr1:44800377-44805990 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Aged mice homozygous for a null allele develop tumors in various organs at an accelerated rate while mouse embryonic fibroblasts are hypersensitive to the induction of HIF-1alpha under hypoxic conditions or by nickel and cobalt ion treatments. Homozygotes for another null allele are overtly normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    52
  • cDNA Data
    6
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028680 Ensembl Gene Model | MGI Sequence Detail 5309 C57BL/6J ±  kb
    transcript ENSMUST00000076859 Ensembl | MGI Sequence Detail 2378 Not Applicable  
    polypeptide ENSMUSP00000076130 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39603
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:24944 Donohue PJ, et al., Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem. 1995 Apr 28;270(17):10351-7
    • Latest
      J:347359 Fu J, et al., Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun. 2024 Apr 11;15(1):3149
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory