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Fap Gene Detail
Summary
  • Symbol
    Fap
  • Name
    fibroblast activation protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:109608
    NCBI Gene: 14089
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:62331280-62404365 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1634 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109608
 protein coding gene Chr2:62331280-62404419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025771
 protein coding gene Chr2:62190075-62269099 (-)
A/J MGP_AJ_G0025747
 protein coding gene Chr2:59807334-59882366 (-)
AKR/J MGP_AKRJ_G0025717
 protein coding gene Chr2:61406163-61481355 (-)
BALB/cJ MGP_BALBcJ_G0025742
 protein coding gene Chr2:59916049-59997474 (-)
C3H/HeJ MGP_C3HHeJ_G0025503
 protein coding gene Chr2:61518258-61595149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026189
 protein coding gene Chr2:64010754-64088502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023593
 protein coding gene Chr2:57326022-57400271 (-)
CAST/EiJ MGP_CASTEiJ_G0024967
 protein coding gene Chr2:61589424-61666483 (-)
CBA/J MGP_CBAJ_G0025483
 protein coding gene Chr2:66437457-66528805 (-)
DBA/2J MGP_DBA2J_G0025614
 protein coding gene Chr2:59388725-59462566 (-)
FVB/NJ MGP_FVBNJ_G0025576
 protein coding gene Chr2:58910745-58984974 (-)
LP/J MGP_LPJ_G0025702
 protein coding gene Chr2:62020805-62094776 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025607
 protein coding gene Chr2:68141764-68221688 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026246
 protein coding gene Chr2:61480000-61556617 (-)
PWK/PhJ MGP_PWKPhJ_G0024708
 protein coding gene Chr2:59254772-59328468 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024515
 protein coding gene Chr2:61628138-61703798 (-)
WSB/EiJ MGP_WSBEiJ_G0025035
 protein coding gene Chr2:61802927-61882196 (-)



Homology
more
  • Human Ortholog
    FAP, fibroblast activation protein alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAP, fibroblast activation protein alpha
  • Synonyms
    DPPIV, FAPA, FAPalpha, SIMP
  • Links
    NCBI Gene ID: 2191
    neXtProt AC: NX_Q12884
    UniProt: Q12884

  • Chr Location
    2q24.2; chr2:162170684-162245151 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Mice homozygous for a targeted null mutations exhibit no discernable phenotype; mice are viable and fertile with no change in cancer susceptibility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    51
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    991
  • Tissues
    84
  • cDNA Data
    14
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14089 NCBI Gene Model | MGI Sequence Detail 73086 C57BL/6J ±  kb
transcript NM_007986 RefSeq | MGI Sequence Detail 2704 ZRU/MplStud  
polypeptide P97321 UniProt | EBI | MGI Sequence Detail 761 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 16
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39607
References
more
  • Summaries
    All 64
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 26
  • Earliest
    J:40036 Niedermeyer J, et al., Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. Int J Cancer. 1997 MAY 2;71(3):383-389
  • Latest
    J:358406 Amrute JM, et al., Targeting immune-fibroblast cell communication in heart failure. Nature. 2024 Nov;635(8038):423-433
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory