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Mia Gene Detail
Summary
  • Symbol
    Mia
  • Name
    MIA SH3 domain containing
  • Synonyms
    Cdrap, Mia1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109615
    NCBI Gene: 12587
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26879166-26880574 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109615
 protein coding gene Chr7:26879166-26880582 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031900
 protein coding gene Chr7:25797319-25798733 (-)
A/J MGP_AJ_G0031879
 protein coding gene Chr7:25192533-25193946 (-)
AKR/J MGP_AKRJ_G0031809
 protein coding gene Chr7:25858733-25860146 (-)
BALB/cJ MGP_BALBcJ_G0031884
 protein coding gene Chr7:25416828-25418241 (-)
C3H/HeJ MGP_C3HHeJ_G0031606
 protein coding gene Chr7:26238992-26240407 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032349
 protein coding gene Chr7:26651857-26653272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029401
 protein coding gene Chr7:26430380-26431798 (-)
CAST/EiJ MGP_CASTEiJ_G0030941
 protein coding gene Chr7:19539270-19540680 (-)
CBA/J MGP_CBAJ_G0031571
 protein coding gene Chr7:27817512-27818927 (-)
DBA/2J MGP_DBA2J_G0031723
 protein coding gene Chr7:24994154-24995569 (-)
FVB/NJ MGP_FVBNJ_G0031679
 protein coding gene Chr7:25077643-25079058 (-)
LP/J MGP_LPJ_G0031803
 protein coding gene Chr7:26138938-26140352 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031714
 protein coding gene Chr7:27430236-27431651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032380
 protein coding gene Chr7:25390522-25391937 (-)
PWK/PhJ MGP_PWKPhJ_G0030665
 protein coding gene Chr7:20024361-20025767 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030499
 protein coding gene Chr7:16379404-16380817 (-)
WSB/EiJ MGP_WSBEiJ_G0031049
 protein coding gene Chr7:25677274-25678688 (-)



Homology
more
  • Human Ortholog
    MIA, MIA SH3 domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIA, MIA SH3 domain containing
  • Synonyms
    CD-RAP, MIA1
  • Links
    NCBI Gene ID: 8190
    neXtProt AC: NX_Q16674
    UniProt: Q16674

  • Chr Location
    19q13.2; chr19:40771648-40777490 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile but display alterations in the fibrillar ultrastructure of cartilage as well as minor changes in the number and morphology of chondrocytic microvilli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    932
  • Tissues
    60
  • cDNA Data
    26
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12587 NCBI Gene Model | MGI Sequence Detail 1409 C57BL/6J ±  kb
transcript NM_019394 RefSeq | MGI Sequence Detail 583 ZRU/MplStud  
polypeptide Q61865 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 1
    cDNA 28
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39614
References
more
  • Summaries
    All 44
    Developmental Gene Expression 15
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:43389 Blesch A, et al., Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res. 1994 Nov 1;54(21):5695-701
  • Latest
    J:344529 Staebler S, et al., MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy. Cells. 2023 Jan 5;12(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory