Ccr10 MGI Mouse Gene Detail - MGI:1096320 - C-C motif chemokine receptor 10

Symbol

Ccr10
Name

C-C motif chemokine receptor 10
Synonyms

CCR10, Cmkbr9, GPR2

Feature Type

protein coding gene
IDs

MGI:1096320
NCBI Gene: 12777
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:101063824-101066269 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.34 cM
Mapping Data

2 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096320	protein coding gene	Chr11:101063823-101066269 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019186	protein coding gene	Chr11:104002748-104005175 (-)
A/J	MGP_AJ_G0019154	protein coding gene	Chr11:99634918-99637351 (-)
AKR/J	MGP_AKRJ_G0019123	protein coding gene	Chr11:102732621-102735067 (-)
BALB/cJ	MGP_BALBcJ_G0019128	protein coding gene	Chr11:100126187-100128633 (-)
C3H/HeJ	MGP_C3HHeJ_G0018937	protein coding gene	Chr11:102901912-102904367 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019577	protein coding gene	Chr11:107221751-107224197 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017203	protein coding gene	Chr11:97054037-97056447 (-)
CAST/EiJ	MGP_CASTEiJ_G0018491	protein coding gene	Chr11:103892983-103895456 (-)
CBA/J	MGP_CBAJ_G0018906	protein coding gene	Chr11:111681789-111684235 (-)
DBA/2J	MGP_DBA2J_G0019018	protein coding gene	Chr11:99165753-99168184 (-)
FVB/NJ	MGP_FVBNJ_G0019008	protein coding gene	Chr11:98712411-98714848 (-)
LP/J	MGP_LPJ_G0019087	protein coding gene	Chr11:104549220-104551669 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019039	protein coding gene	Chr11:111247881-111250318 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019615	protein coding gene	Chr11:103051576-103054027 (-)
PWK/PhJ	MGP_PWKPhJ_G0018254	protein coding gene	Chr11:100217766-100220287 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018046	protein coding gene	Chr11:102796307-102798746 (-)
WSB/EiJ	MGP_WSBEiJ_G0018540	protein coding gene	Chr11:103052508-103054965 (-)

Human Ortholog

CCR10, C-C motif chemokine receptor 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCR10, C-C motif chemokine receptor 10
Synonyms

GPR2
Links

HGNC:4474

NCBI Gene ID: 2826

neXtProt AC: NX_P46092

UniProt: P46092
Chr Location

17q21.2; chr17:42678889-42683917 (-) GRCh38

MGI Vertebrate Homology

Ccr10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCR10
Gene Tree

Ccr10

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Phenotype Summary

31 phenotypes from 3 alleles in 4 genetic backgrounds
5 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

1 involving Ccr10
Incidental Mutations

CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null mutation are viable and fertile, without any detectable neurological abnormalities.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ccr10

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS25454.1

Ensembl

ENSMUSG00000044052 (Evidence)
NCBI Gene

12777

			Length	Strain/Species	Flank
genomic	12777	NCBI Gene Model \| MGI Sequence Detail	2446	C57BL/6J	± kb
transcript	NM_007721	RefSeq \| MGI Sequence Detail	1725	Not Specified
polypeptide	Q9JL21	UniProt \| EBI \| MGI Sequence Detail	362	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001198 C-C chemokine receptor type 10

(term hierarchy)
InterPro Domains

IPR005382 CC chemokine receptor 10

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 7

cDNA 6

Other 1

Microarray probesets 2

Summaries

All 57

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 30
Earliest

J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
Latest

J:342323 Chang C, et al., Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits. Cell Rep. 2023 Oct 31;42(10):113274

TSS for Ccr10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110918	Chr11:101066266-101066270 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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