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Ephb1 Gene Detail
Summary
  • Symbol
    Ephb1
  • Name
    Eph receptor B1
  • Synonyms
    C130099E04Rik, Cek6, Elk, Elkh, Hek6, Net
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096337
    NCBI Gene: 270190
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:101799327-102231892 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096337
 protein coding gene Chr9:101799327-102231892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035184
 protein coding gene Chr9:103440566-103915411 (-)
A/J MGP_AJ_G0035164
 protein coding gene Chr9:99747486-100186059 (-)
AKR/J MGP_AKRJ_G0035096
 protein coding gene Chr9:102209067-102655393 (-)
BALB/cJ MGP_BALBcJ_G0035157
 protein coding gene Chr9:99457782-99895002 (-)
C3H/HeJ MGP_C3HHeJ_G0034867
 protein coding gene Chr9:102625740-103067485 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035677
 protein coding gene Chr9:106366809-106817669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032576
 protein coding gene Chr9:97356233-97788159 (-)
CAST/EiJ MGP_CASTEiJ_G0034179
 protein coding gene Chr9:102430219-102875562 (-)
CBA/J MGP_CBAJ_G0034836
 protein coding gene Chr9:110072877-110553589 (-)
DBA/2J MGP_DBA2J_G0034997
 protein coding gene Chr9:99250793-99686866 (-)
FVB/NJ MGP_FVBNJ_G0034945
 protein coding gene Chr9:98049122-98483056 (-)
LP/J MGP_LPJ_G0035073
 protein coding gene Chr9:103660916-104116363 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034984
 protein coding gene Chr9:111932719-112388052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035699
 protein coding gene Chr9:102462729-102909612 (-)
PWK/PhJ MGP_PWKPhJ_G0033886
 protein coding gene Chr9:99485020-99922376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033721
 protein coding gene Chr9:102504319-102939468 (-)
WSB/EiJ MGP_WSBEiJ_G0034299
 protein coding gene Chr9:102341744-102788580 (-)



Homology
more
  • Human Ortholog
    EPHB1, EPH receptor B1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHB1, EPH receptor B1
  • Synonyms
    ELK, EPHT2, Hek6, NET
  • Links
    NCBI Gene ID: 2047
    neXtProt AC: NX_P54762
    UniProt: P54762

  • Chr Location
    3q22.2; chr3:134795260-135260467 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EPHB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display marked reductions of the ipsilateral optic tract. Homozygotes for one null allele show reduced corticospinal tract and abnormal anterior commissure axon crossing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1132
  • Tissues
    257
  • cDNA Data
    57
  • Literature Summary
    106
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 270190 NCBI Gene Model | MGI Sequence Detail 432566 C57BL/6J ±  kb
    transcript NM_173447 RefSeq | MGI Sequence Detail 4686 C57BL/6  
    polypeptide Q8CBF3 UniProt | EBI | MGI Sequence Detail 984 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007129 ephrin type-B receptor 1
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR042819 EphB1 , SAM domain
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR034231 Ephrin type-B receptor 1, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      Q8CBF3 4 sites, 3 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 60
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32154, MGI:105114, MGI:2143306, MGI:3712490
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 106
      Gene Ontology 26
      Phenotypes 56
    • Earliest
      J:23894 Mori T, et al., Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995 Apr;29(2):325-35
    • Latest
      J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory