Gckr MGI Mouse Gene Detail - MGI:1096345 - glucokinase regulatory protein

Symbol

Gckr
Name

glucokinase regulatory protein
Synonyms

GKRP, MGC:19300

Feature Type

protein coding gene
IDs

MGI:1096345
NCBI Gene: 231103
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr5:31454787-31484658 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.27 cM
Mapping Data

2 experiments

SNPs within 2kb

938 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096345	protein coding gene	Chr5:31454594-31484658 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029424	protein coding gene	Chr5:29295312-29328057 (+)
A/J	MGP_AJ_G0029390	protein coding gene	Chr5:28329550-28361789 (+)
AKR/J	MGP_AKRJ_G0029340	protein coding gene	Chr5:29479782-29511405 (+)
BALB/cJ	MGP_BALBcJ_G0029401	protein coding gene	Chr5:28843670-28877079 (+)
C3H/HeJ	MGP_C3HHeJ_G0029122	protein coding gene	Chr5:29510580-29542152 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029854	protein coding gene	Chr5:31104560-31138105 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027092	protein coding gene	Chr5:25978752-26003335 (+)
CAST/EiJ	MGP_CASTEiJ_G0028532	protein coding gene	Chr5:28583892-28622561 (+)
CBA/J	MGP_CBAJ_G0029090	protein coding gene	Chr5:31684121-31738377 (+)
DBA/2J	MGP_DBA2J_G0029239	protein coding gene	Chr5:28507212-28537462 (+)
FVB/NJ	MGP_FVBNJ_G0029197	protein coding gene	Chr5:27923938-27954400 (+)
LP/J	MGP_LPJ_G0029324	protein coding gene	Chr5:29744877-29777689 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029226	protein coding gene	Chr5:32544712-32580573 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029888	protein coding gene	Chr5:28994909-29028430 (+)
PWK/PhJ	MGP_PWKPhJ_G0028257	protein coding gene	Chr5:27631226-27663826 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028088	protein coding gene	Chr5:28388679-28427691 (+)
WSB/EiJ	MGP_WSBEiJ_G0028613	protein coding gene	Chr5:29059579-29091117 (+)

Human Ortholog

GCKR, glucokinase regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GCKR, glucokinase regulator
Synonyms

FGQTL5, GKRP
Links

HGNC:4196

NCBI Gene ID: 2646

neXtProt AC: NX_Q14397

UniProt: Q14397
Chr Location

2p23.3; chr2:27496839-27523684 (+) GRCh38

MGI Vertebrate Homology

Gckr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GCKR
Gene Tree

Gckr

Diseases

2 with human GCKR associations

				Human Disease	Mouse Models
				end stage renal disease IDs end stage renal disease DOID:783
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 3 alleles in 4 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

5
Radiation induced

2
Spontaneous

1
Targeted

7
Genomic Mutations

5 involving Gckr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis.

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All GO Annotations

46
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

5
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gckr

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All Sequences

42
RefSeq

8
UniProt

2
CCDS

CCDS19182.1, CCDS89900.1

Ensembl

ENSMUSG00000059434 (Evidence)
NCBI Gene

231103

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059434	Ensembl Gene Model \| MGI Sequence Detail	29872	C57BL/6J	± kb
transcript	ENSMUST00000201166	Ensembl \| MGI Sequence Detail	2272	Not Applicable
polypeptide	ENSMUSP00000144202	Ensembl \| MGI Sequence Detail	623	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007896 glucokinase regulatory protein

(term hierarchy)
InterPro Domains

IPR005486 Glucokinase regulatory protein, conserved site

IPR040190 N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein

IPR001347 SIS domain

IPR046348 SIS domain superfamily
GlyGen

Q91X44 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 2

Summaries

All 65

Developmental Gene Expression 2

Diseases 1

Gene Ontology 9

Phenotypes 36
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:357543 Buziau AM, et al., Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency. Mol Metab. 2024 Sep;87:101984

TSS for Gckr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45702	Chr5:31454895-31454930 (+)	126 bp
Tssr45703	Chr5:31454941-31454946 (+)	157 bp
Tssr45704	Chr5:31454947-31454960 (+)	167 bp
Tssr45705	Chr5:31455138-31455141 (+)	353 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24