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Sema3f Gene Detail
Summary
  • Symbol
    Sema3f
  • Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
  • Synonyms
    Sema IV, Semak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096347
    NCBI Gene: 20350
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107558699-107587674 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.91 cM, cytoband F2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096347
 protein coding gene Chr9:107558698-107587674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035268
 protein coding gene Chr9:109574501-109605255 (-)
A/J MGP_AJ_G0035247
 protein coding gene Chr9:105580427-105609372 (-)
AKR/J MGP_AKRJ_G0035179
 protein coding gene Chr9:108215048-108245983 (-)
BALB/cJ MGP_BALBcJ_G0035241
 protein coding gene Chr9:105248167-105277377 (-)
C3H/HeJ MGP_C3HHeJ_G0034951
 protein coding gene Chr9:108612071-108640937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035761
 protein coding gene Chr9:112558121-112587847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032659
 protein coding gene Chr9:103008109-103037175 (-)
CAST/EiJ MGP_CASTEiJ_G0034262
 protein coding gene Chr9:108547238-108580411 (-)
CBA/J MGP_CBAJ_G0034919
 protein coding gene Chr9:116524988-116555572 (-)
DBA/2J MGP_DBA2J_G0035080
 protein coding gene Chr9:105031684-105062873 (-)
FVB/NJ MGP_FVBNJ_G0035028
 protein coding gene Chr9:103802136-103830958 (-)
LP/J MGP_LPJ_G0035156
 protein coding gene Chr9:109769076-109801332 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035067
 protein coding gene Chr9:118140648-118172555 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035782
 protein coding gene Chr9:108487760-108520711 (-)
PWK/PhJ MGP_PWKPhJ_G0033969
 protein coding gene Chr9:105353444-105383001 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033804
 protein coding gene Chr9:108540656-108571358 (-)
WSB/EiJ MGP_WSBEiJ_G0034383
 protein coding gene Chr9:108368599-108397409 (-)



Homology
more
  • Human Ortholog
    SEMA3F, semaphorin 3F
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA3F, semaphorin 3F
  • Synonyms
    SEMA4, SEMA-IV, SEMAK
  • Links
    NCBI Gene ID: 6405
    neXtProt AC: NX_Q13275
    UniProt: Q13275

  • Chr Location
    3p21.31; chr3:50155045-50189075 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in neuronal defects including impaired CNS axon pathfinding, and PNS and limbic system circuitry. Mice homozygous for a knock-out allele exhibit increased lymphatic branching complexity and LEC numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1089
  • Tissues
    214
  • cDNA Data
    73
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034684 Ensembl Gene Model | MGI Sequence Detail 28976 C57BL/6J ±  kb
    transcript ENSMUST00000192727 Ensembl | MGI Sequence Detail 2383 Not Applicable  
    polypeptide ENSMUSP00000141865 Ensembl | MGI Sequence Detail 785 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 77
      Other 10

      Microarray probesets 5
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 83
      Gene Ontology 13
      Phenotypes 41
    • Earliest
      J:49908 Chedotal A, et al., Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998 Nov;125(21):4313-23
    • Latest
      J:353479 Erickson AG, et al., Motor innervation directs the correct development of the mouse sympathetic nervous system. Nat Commun. 2024 Aug 16;15(1):7065
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory