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Cd151 Gene Detail
Summary
  • Symbol
    Cd151
  • Name
    CD151 antigen
  • Synonyms
    PETA-3, SFA-1, Tspan24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096360
    NCBI Gene: 12476
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141047305-141051386 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096360
 protein coding gene Chr7:141047275-141051394 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033234
 protein coding gene Chr7:146660273-146664388 (+)
A/J MGP_AJ_G0033216
 protein coding gene Chr7:142465425-142469794 (+)
AKR/J MGP_AKRJ_G0033148
 protein coding gene Chr7:146416375-146420491 (+)
BALB/cJ MGP_BALBcJ_G0033217
 protein coding gene Chr7:142209851-142213968 (+)
C3H/HeJ MGP_C3HHeJ_G0032931
 protein coding gene Chr7:146151768-146155888 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033728
 protein coding gene Chr7:152011432-152015549 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030701
 protein coding gene Chr7:143672653-143676767 (+)
CAST/EiJ MGP_CASTEiJ_G0032261
 protein coding gene Chr7:138465760-138469880 (+)
CBA/J MGP_CBAJ_G0032903
 protein coding gene Chr7:157171238-157175355 (+)
DBA/2J MGP_DBA2J_G0033055
 protein coding gene Chr7:140409809-140413927 (+)
FVB/NJ MGP_FVBNJ_G0033008
 protein coding gene Chr7:140324723-140328840 (+)
LP/J MGP_LPJ_G0033150
 protein coding gene Chr7:148152761-148156883 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033041
 protein coding gene Chr7:157805566-157809725 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033748
 protein coding gene Chr7:145374173-145378290 (+)
PWK/PhJ MGP_PWKPhJ_G0031965
 protein coding gene Chr7:133694940-133699049 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032372
 protein coding gene Chr7:146322719-146326895 (+)



Homology
more
  • Human Ortholog
    CD151, CD151 molecule (Raph blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD151, CD151 molecule (Raph blood group)
  • Synonyms
    EBS7, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
  • Links
    NCBI Gene ID: 977
    neXtProt AC: NX_P48509
    UniProt: P48509

  • Chr Location
    11p15.5; chr11:832887-839831 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD151 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 4 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display increased bleeding time, impaired keratinocyte migration, hyperproliferation of stimulated T cells, impaired pathologic angiogenesis in several in vivo assays, and kidney abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025510 Ensembl Gene Model | MGI Sequence Detail 4082 C57BL/6J ±  kb
    transcript ENSMUST00000106000 Ensembl | MGI Sequence Detail 1865 Not Applicable  
    polypeptide ENSMUSP00000101622 Ensembl | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 4
      cDNA 12
      Primer pair 5

      Microarray probesets 9
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:42363 Hasegawa H, et al., Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Biochim Biophys Acta. 1997 Aug 7;1353(2):125-30
    • Latest
      J:287748 Jankovicova J, et al., Expression and distribution of CD151 as a partner of alpha6 integrin in male germ cells. Sci Rep. 2020 Mar 9;10(1):4374
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory