Nrxn2 MGI Mouse Gene Detail - MGI:1096362

Symbol

Nrxn2
Name

neurexin II
Synonyms

6430591O13Rik, mKIAA0921, neurexin II alpha, neurexin II beta

Feature Type

protein coding gene
IDs

MGI:1096362
NCBI Gene: 18190
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr19:6468786-6583247 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.65 cM
Mapping Data

1 experiment

SNPs within 2kb

463 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096362	protein coding gene	Chr19:6468761-6594199 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024764	protein coding gene	Chr19:3475480-3613249 (+)
A/J	MGP_AJ_G0024730	protein coding gene	Chr19:3285382-3411334 (+)
AKR/J	MGP_AKRJ_G0024703	protein coding gene	Chr19:3382739-3511657 (+)
BALB/cJ	MGP_BALBcJ_G0024730	protein coding gene	Chr19:3282682-3410289 (+)
C3H/HeJ	MGP_C3HHeJ_G0024498	protein coding gene	Chr19:3403250-3532862 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025176	protein coding gene	Chr19:3525368-3671457 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022610	protein coding gene	Chr19:3208356-3338550 (+)
CAST/EiJ	MGP_CASTEiJ_G0023970	protein coding gene	Chr19:3428770-3555090 (+)
CBA/J	MGP_CBAJ_G0024470	protein coding gene	Chr19:3696888-3855960 (+)
DBA/2J	MGP_DBA2J_G0024597	protein coding gene	Chr19:3272933-3398114 (+)
FVB/NJ	MGP_FVBNJ_G0024563	protein coding gene	Chr19:3289624-3416991 (+)
LP/J	MGP_LPJ_G0024683	protein coding gene	Chr19:3438516-3572363 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024592	protein coding gene	Chr19:3520413-3656860 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025224	protein coding gene	Chr19:3407866-3537527 (+)
PWK/PhJ	MGP_PWKPhJ_G0023716	protein coding gene	Chr19:3307520-3436346 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023521	protein coding gene	Chr19:3367029-3493361 (+)
WSB/EiJ	MGP_WSBEiJ_G0024032	protein coding gene	Chr19:3423913-3553847 (+)

Human Ortholog

NRXN2, neurexin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRXN2, neurexin 2
Links

HGNC:8009

NCBI Gene ID: 9379

neXtProt AC: NX_P58401, NX_Q9P2S2

UniProt: P58401, Q9P2S2
Chr Location

11q13.1; chr11:64606174-64723197 (-) GRCh38

MGI Vertebrate Homology

Nrxn2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NRXN2
Gene Tree

Nrxn2

Diseases

1 with Nrxn2 mouse models

Human Disease

Mouse Models

autism spectrum disorder

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 5 alleles in 5 genetic backgrounds
16 phenotypes from multigenic genotypes
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

6
Gene trapped

14
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

91 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are generally non-viable; surviving homozygotes show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures.

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All GO Annotations

43
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

41
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nrxn2

ZFIN nrxn2a

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All Sequences

91
RefSeq

8
UniProt

12
CCDS

CCDS57132.1, CCDS57133.1, CCDS89326.1, CCDS89327.1

Ensembl

ENSMUSG00000033768 (Evidence)
NCBI Gene

18190

			Length	Strain/Species	Flank
genomic	18190	NCBI Gene Model \| MGI Sequence Detail	114462	C57BL/6J	± kb
transcript	NM_001369363	RefSeq \| MGI Sequence Detail	6663	C57BL/6
polypeptide	E9Q7X7	UniProt \| EBI \| MGI Sequence Detail	1710	Not Applicable

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UniProt

12 Sequences
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR001791 Laminin G domain

IPR050372 Neurexin-related cell adhesion and synaptic protein

IPR003585 Neurexin/syndecan/glycophorin C

IPR027789 Syndecan/Neurexin domain
GlyGen

E9Q7X7 9 sites, 7 N-linked glycans (6 sites), 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 17

Primer pair 2

Other 3

Microarray probesets 7

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MGI:2444066

Summaries

All 77

Developmental Gene Expression 7

Diseases 1

Gene Ontology 10

Phenotypes 41
Earliest

J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
Latest

J:353360 Cesari E, et al., Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184

TSS for Nrxn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154660	Chr19:6468763-6468840 (+)	16 bp
Tssr154661	Chr19:6547442-6547479 (+)	78,675 bp
Tssr154662	Chr19:6547482-6547517 (+)	78,714 bp
Tssr154663	Chr19:6547617-6547696 (+)	78,871 bp
Tssr154664	Chr19:6547704-6547717 (+)	78,925 bp
Tssr154665	Chr19:6547754-6547774 (+)	78,978 bp
Tssr154666	Chr19:6547788-6547794 (+)	79,005 bp
Tssr154667	Chr19:6547802-6547875 (+)	79,053 bp
Tssr154668	Chr19:6547907-6547951 (+)	79,143 bp
Tssr154669	Chr19:6547962-6547973 (+)	79,182 bp
Tssr154670	Chr19:6547979-6548009 (+)	79,208 bp
Tssr154671	Chr19:6548054-6548067 (+)	79,275 bp
Tssr154672	Chr19:6548111-6548119 (+)	79,329 bp
Tssr154673	Chr19:6548196-6548203 (+)	79,414 bp
Tssr154674	Chr19:6581176-6581259 (+)	112,432 bp
Tssr5425	Chr19:6581636-6581647 (+)	112,856 bp
Tssr154675	Chr19:6582260-6582270 (+)	113,479 bp
Tssr154676	Chr19:6582515-6582528 (+)	113,736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24