Erf MGI Mouse Gene Detail - MGI:109637

Symbol

Erf
Name

Ets2 repressor factor

Feature Type

protein coding gene
IDs

MGI:109637
NCBI Gene: 13875
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:24941986-24950186 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 13.73 cM
Mapping Data

1 experiment

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109637	protein coding gene	Chr7:24941985-24950522 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031858	protein coding gene	Chr7:23694977-23703105 (-)
A/J	MGP_AJ_G0031837	protein coding gene	Chr7:23088677-23097720 (-)
AKR/J	MGP_AKRJ_G0031766	protein coding gene	Chr7:23627728-23637321 (-)
BALB/cJ	MGP_BALBcJ_G0031844	protein coding gene	Chr7:23296608-23306684 (-)
C3H/HeJ	MGP_C3HHeJ_G0031563	protein coding gene	Chr7:24059556-24067630 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032306	protein coding gene	Chr7:24478183-24487962 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029361	protein coding gene	Chr7:24511044-24519252 (-)
CAST/EiJ	MGP_CASTEiJ_G0030903	protein coding gene	Chr7:17527959-17536004 (-)
CBA/J	MGP_CBAJ_G0031528	protein coding gene	Chr7:25379008-25390306 (-)
DBA/2J	MGP_DBA2J_G0031682	protein coding gene	Chr7:22987971-22996186 (-)
FVB/NJ	MGP_FVBNJ_G0031635	protein coding gene	Chr7:22988576-22998126 (-)
LP/J	MGP_LPJ_G0031761	protein coding gene	Chr7:23993908-24003819 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031672	protein coding gene	Chr7:25099262-25113442 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032338	protein coding gene	Chr7:23331074-23342047 (-)
PWK/PhJ	MGP_PWKPhJ_G0030627	protein coding gene	Chr7:17927092-17935823 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030458	protein coding gene	Chr7:14647437-14659446 (-)
WSB/EiJ	MGP_WSBEiJ_G0031006	protein coding gene	Chr7:23507271-23515180 (-)

Human Ortholog

ERF, ETS2 repressor factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERF, ETS2 repressor factor
Synonyms

CHYTS, CRS4, PE-2, PE2
Links

HGNC:3444

NCBI Gene ID: 2077

neXtProt AC: NX_P50548

UniProt: P50548
Chr Location

19q13.2; chr19:42247569-42255128 (-) GRCh38

MGI Vertebrate Homology

Erf stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ERF
Gene Tree

Erf

Diseases

1 with human ERF associations

				Human Disease	Mouse Models
				craniosynostosis IDs craniosynostosis DOID:2340 ICD10CM:Q75.0 MESH:D003398 NCI:C84655 OMIM:182212 OMIM:600593 ORDO:1531 UMLS_CUI:C0010278

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

33 phenotypes from 4 alleles in 5 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Gene trapped

28
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality around E10.5, reduced size, brain hypoplasia, defects in extraembryonic tissue formation affecting the chorion, allantois, placental labyrinth and umbilical cord, and increase in apoptosis.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

916
Tissues

115
cDNA Data

35
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase erf

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All Sequences

43
RefSeq

8
UniProt

3
CCDS

CCDS20978.1

Ensembl

ENSMUSG00000040857 (Evidence)
NCBI Gene

13875

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040857	Ensembl Gene Model \| MGI Sequence Detail	8201	C57BL/6J	± kb
transcript	ENSMUST00000045847	Ensembl \| MGI Sequence Detail	3505	Not Applicable
polypeptide	ENSMUSP00000041912	Ensembl \| MGI Sequence Detail	551	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007172 ETS domain-containing transcription factor ERF

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P70459 1 site, 1 O-linked glycan (1 site)

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All nucleic 40

Genomic 1

cDNA 35

Primer pair 2

Other 2

Microarray probesets 7

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MGD-MRK-39636

Summaries

All 52

Developmental Gene Expression 16

Gene Ontology 4

Phenotypes 17
Earliest

J:39443 Liu D, et al., ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. Oncogene. 1997 Mar 27;14(12):1445-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Erf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71213	Chr7:24950296-24950306 (-)	-115 bp
Tssr71212	Chr7:24950145-24950163 (-)	32 bp
Tssr71211	Chr7:24947849-24947890 (-)	2,316 bp
Tssr71210	Chr7:24945132-24945135 (-)	5,052 bp
Tssr71209	Chr7:24944944-24944957 (-)	5,235 bp
Tssr71208	Chr7:24944892-24944906 (-)	5,287 bp
Tssr71207	Chr7:24944865-24944878 (-)	5,314 bp
Tssr71206	Chr7:24944601-24944632 (-)	5,569 bp
Tssr71205	Chr7:24944532-24944569 (-)	5,635 bp
Tssr71204	Chr7:24944425-24944440 (-)	5,753 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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