Traip MGI Mouse Gene Detail - MGI:1096377

Symbol

Traip
Name

TRAF-interacting protein
Synonyms

Trip

Feature Type

protein coding gene
IDs

MGI:1096377
NCBI Gene: 22036
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:107828158-107849469 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.07 cM
Mapping Data

2 experiments

SNPs within 2kb

469 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096377	protein coding gene	Chr9:107827335-107849469 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035275	protein coding gene	Chr9:109865077-109887208 (+)
A/J	MGP_AJ_G0035254	protein coding gene	Chr9:105854277-105876348 (+)
AKR/J	MGP_AKRJ_G0035186	protein coding gene	Chr9:108495106-108517240 (+)
BALB/cJ	MGP_BALBcJ_G0035248	protein coding gene	Chr9:105524663-105546735 (+)
C3H/HeJ	MGP_C3HHeJ_G0034958	protein coding gene	Chr9:108892836-108914905 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035768	protein coding gene	Chr9:112837960-112860099 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032666	protein coding gene	Chr9:103287287-103309769 (+)
CAST/EiJ	MGP_CASTEiJ_G0034269	protein coding gene	Chr9:108849051-108871284 (+)
CBA/J	MGP_CBAJ_G0034926	protein coding gene	Chr9:116831781-116858905 (+)
DBA/2J	MGP_DBA2J_G0035087	protein coding gene	Chr9:105308763-105330895 (+)
FVB/NJ	MGP_FVBNJ_G0035035	protein coding gene	Chr9:104075002-104097143 (+)
LP/J	MGP_LPJ_G0035163	protein coding gene	Chr9:110060500-110082631 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035074	protein coding gene	Chr9:118428606-118451581 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035789	protein coding gene	Chr9:108771429-108793559 (+)
PWK/PhJ	MGP_PWKPhJ_G0033976	protein coding gene	Chr9:105630798-105653082 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033811	protein coding gene	Chr9:108835068-108857310 (+)
WSB/EiJ	MGP_WSBEiJ_G0034390	protein coding gene	Chr9:108652949-108675099 (+)

Human Ortholog

TRAIP, TRAF interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAIP, TRAF interacting protein
Synonyms

RNF206, SCKL9, TRIP
Links

HGNC:30764

NCBI Gene ID: 10293

neXtProt AC: NX_Q9BWF2

UniProt: Q9BWF2
Chr Location

3p21.31; chr3:49828601-49856574 (-) GRCh38

MGI Vertebrate Homology

Traip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRAIP
Gene Tree

Traip

Diseases

1 with human TRAIP associations

				Human Disease	Mouse Models
				Seckel syndrome 9 IDs Seckel syndrome 9 DOID:0070005 OMIM:616777

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

8
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality at prior to E8.5, embryonic growth retardation, decreased embryonic size, decreased cell proliferation and increased apoptosis.

less

All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

39
cDNA Data

33
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase traip

less

All Sequences

54
RefSeq

13
UniProt

2
CCDS

CCDS23511.1

Ensembl

ENSMUSG00000032586 (Evidence)
NCBI Gene

22036

			Length	Strain/Species	Flank
genomic	22036	NCBI Gene Model \| MGI Sequence Detail	21312	C57BL/6J	± kb
transcript	NM_001410472	RefSeq \| MGI Sequence Detail	3038	ZRU/MplStud
polypeptide	Q8VIG6	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000016606 E3 ubiquitin-protein ligase TRAIP

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR052639 TRAIP E3 ubiquitin-protein ligase

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

less

All nucleic 36

Genomic 1

cDNA 34

Primer pair 1

Microarray probesets 7

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 4
Earliest

J:39150 Logue SF, et al., Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Behav Neurosci. 1997 Feb;111(1):104-13
Latest

J:219064 Zhang M, et al., TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J Exp Med. 2012 Sep 24;209(10):1703-11

TSS for Traip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87036	Chr9:107828151-107828190 (+)	13 bp
Tssr87037	Chr9:107838703-107838706 (+)	10,547 bp
Tssr87038	Chr9:107849299-107849313 (+)	21,148 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24