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Fgf15 Gene Detail
Summary
  • Symbol
    Fgf15
  • Name
    fibroblast growth factor 15
  • Synonyms
    FGF19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096383
    NCBI Gene: 14170
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144450269-144454690 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096383
 protein coding gene Chr7:144450268-144454690 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033293
 protein coding gene Chr7:150273135-150277563 (+)
A/J MGP_AJ_G0033276
 protein coding gene Chr7:145921490-145925926 (+)
AKR/J MGP_AKRJ_G0033207
 protein coding gene Chr7:150016499-150020953 (+)
BALB/cJ MGP_BALBcJ_G0033276
 protein coding gene Chr7:145686231-145690745 (+)
C3H/HeJ MGP_C3HHeJ_G0032990
 protein coding gene Chr7:149777808-149782248 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033786
 protein coding gene Chr7:155692995-155697416 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030759
 protein coding gene Chr7:147073365-147077766 (+)
CAST/EiJ MGP_CASTEiJ_G0032313
 protein coding gene Chr7:142096186-142100665 (+)
CBA/J MGP_CBAJ_G0032963
 protein coding gene Chr7:160990106-160994542 (+)
DBA/2J MGP_DBA2J_G0033117
 protein coding gene Chr7:143883749-143888185 (+)
FVB/NJ MGP_FVBNJ_G0033065
 protein coding gene Chr7:143827723-143832149 (+)
LP/J MGP_LPJ_G0033209
 protein coding gene Chr7:151806656-151811084 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033099
 protein coding gene Chr7:161518273-161522709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033804
 protein coding gene Chr7:148985137-148989573 (+)
PWK/PhJ MGP_PWKPhJ_G0032023
 protein coding gene Chr7:137198823-137203269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031867
 protein coding gene Chr7:135773279-135777698 (+)
WSB/EiJ MGP_WSBEiJ_G0032426
 protein coding gene Chr7:149973127-149977550 (+)



Homology
more
  • Human Ortholog
    FGF19, fibroblast growth factor 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF19, fibroblast growth factor 19
  • Links
    NCBI Gene ID: 9965
    neXtProt AC: NX_O95750
    UniProt: O95750

  • Chr Location
    11q13.3; chr11:69698238-69704022 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to a severe underrepresentation of homozygotes at weaning as well as highly penetrant ventricular septal defects and malalignment of the aorta and pulmonary trunk. No abnormalities in otic induction or otic vesicle formation are observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1565
  • Tissues
    470
  • cDNA Data
    41
  • Literature Summary
    118
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14170 NCBI Gene Model | MGI Sequence Detail 4422 C57BL/6J ±  kb
    transcript NM_008003 RefSeq | MGI Sequence Detail 1809 C57BL/6  
    polypeptide O35622 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 2
      cDNA 45
      Primer pair 10
      Other 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 118
      Gene Ontology 9
      Phenotypes 35
    • Earliest
      J:43066 McWhirter JR, et al., A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997 Sep;124(17):3221-32
    • Latest
      J:354243 Stebbins K, et al., Retinal Input Is Required for the Maintenance of Neuronal Laminae in the Ventrolateral Geniculate Nucleus. eNeuro. 2024 Sep;11(9):ENEURO.0022-24.2024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory