Bcan MGI Mouse Gene Detail - MGI:1096385

Symbol

Bcan
Name

brevican
Synonyms

Cspg7

Feature Type

protein coding gene
IDs

MGI:1096385
NCBI Gene: 12032
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:87894838-87907537 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM
Mapping Data

3 experiments

SNPs within 2kb

349 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096385	protein coding gene	Chr3:87894838-87908458 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027378	protein coding gene	Chr3:88122490-88135207 (-)
A/J	MGP_AJ_G0027342	protein coding gene	Chr3:85131729-85144422 (-)
AKR/J	MGP_AKRJ_G0027308	protein coding gene	Chr3:87226363-87239099 (-)
BALB/cJ	MGP_BALBcJ_G0027351	protein coding gene	Chr3:85225135-85238115 (-)
C3H/HeJ	MGP_C3HHeJ_G0027094	protein coding gene	Chr3:87501817-87517920 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027797	protein coding gene	Chr3:91364002-91376704 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025150	protein coding gene	Chr3:80762754-80775790 (-)
CAST/EiJ	MGP_CASTEiJ_G0026540	protein coding gene	Chr3:87710612-87723493 (-)
CBA/J	MGP_CBAJ_G0027069	protein coding gene	Chr3:94458329-94476071 (-)
DBA/2J	MGP_DBA2J_G0027205	protein coding gene	Chr3:84622075-84634824 (-)
FVB/NJ	MGP_FVBNJ_G0027174	protein coding gene	Chr3:82895099-82908611 (-)
LP/J	MGP_LPJ_G0027313	protein coding gene	Chr3:89088418-89102514 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027193	protein coding gene	Chr3:100713274-100729838 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027855	protein coding gene	Chr3:86978727-86993059 (-)
PWK/PhJ	MGP_PWKPhJ_G0026273	protein coding gene	Chr3:84417574-84430954 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026091	protein coding gene	Chr3:86164071-86178809 (-)
WSB/EiJ	MGP_WSBEiJ_G0026620	protein coding gene	Chr3:87340170-87352851 (-)

Human Ortholog

BCAN, brevican

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCAN, brevican
Synonyms

BEHAB, CSPG7
Links

HGNC:23059

NCBI Gene ID: 63827

neXtProt AC: NX_Q96GW7

UniProt: Q96GW7
Chr Location

1q23.1; chr1:156641390-156659532 (+) GRCh38

MGI Vertebrate Homology

Bcan stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCAN
Gene Tree

Bcan

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Bcan
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in impaired LTP maintenance, but mutant animals show normal behavior and spatial learning capabilities.

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All GO Annotations

32
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1009
Tissues

129
cDNA Data

27
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BCAN

Xenbase bcan

ZFIN bcan

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All Sequences

84
RefSeq

43
UniProt

4
CCDS

CCDS17462.1

Ensembl

ENSMUSG00000004892 (Evidence)
NCBI Gene

12032

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004892	Ensembl Gene Model \| MGI Sequence Detail	12700	C57BL/6J	± kb
transcript	ENSMUST00000090971	Ensembl \| MGI Sequence Detail	3141	Not Applicable
polypeptide	ENSMUSP00000088491	Ensembl \| MGI Sequence Detail	883	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004673 brevican core protein

(term hierarchy)
InterPro Domains

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR050691 Hyaluronan-binding Proteoglycan

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR000538 Link domain

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

Q61361 4 sites, 11 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 33

Genomic 1

cDNA 28

Primer pair 3

Other 1

Microarray probesets 5

Summaries

All 72

Developmental Gene Expression 24

Diseases 1

Gene Ontology 10

Phenotypes 19
Earliest

J:42589 Rauch U, et al., Sequence and chromosomal localization of the mouse brevican gene. Genomics. 1997 Aug 15;44(1):15-21
Latest

J:351222 Reinhard J, et al., Neural extracellular matrix regulates visual sensory motor integration. iScience. 2024 Feb 16;27(2):108846

TSS for Bcan:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33975	Chr3:87908322-87908350 (-)	-799 bp
Tssr33974	Chr3:87908201-87908212 (-)	-670 bp
Tssr33973	Chr3:87908150-87908173 (-)	-625 bp
Tssr33972	Chr3:87907710-87907727 (-)	-182 bp
Tssr33971	Chr3:87907671-87907696 (-)	-147 bp
Tssr33970	Chr3:87907657-87907666 (-)	-125 bp
Tssr33969	Chr3:87907540-87907547 (-)	-7 bp
Tssr33968	Chr3:87907504-87907530 (-)	20 bp
Tssr33967	Chr3:87907495-87907500 (-)	39 bp
Tssr33966	Chr3:87907455-87907487 (-)	66 bp
Tssr33965	Chr3:87903662-87903675 (-)	3,868 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24