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Nrxn1 Gene Detail
Summary
  • Symbol
    Nrxn1
  • Name
    neurexin I
  • Synonyms
    1700062G21Rik, 9330127H16Rik, A230068P09Rik, alpha-latrotoxin receptor (calcium-dependent), mKIAA0578, neurexin I alpha, neurexin I alpha, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096391
    NCBI Gene: 18189
  • Alliance
    gene page
  • Transcription Start Sites
    58 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:90341059-91400499 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 59.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    31965 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096391
 protein coding gene Chr17:90341059-91400587 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024115
 protein coding gene Chr17:93577552-94701577 (-)
A/J MGP_AJ_G0024075
 protein coding gene Chr17:90546053-91623050 (-)
AKR/J MGP_AKRJ_G0024044
 protein coding gene Chr17:92041808-93137528 (-)
BALB/cJ MGP_BALBcJ_G0024076
 protein coding gene Chr17:90341870-91432210 (-)
C3H/HeJ MGP_C3HHeJ_G0023841
 protein coding gene Chr17:92948374-94066350 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024521
 protein coding gene Chr17:96829722-97953278 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021959
 protein coding gene Chr17:85491118-86564748 (-)
CAST/EiJ MGP_CASTEiJ_G0023320
 protein coding gene Chr17:93850651-94994067 (-)
CBA/J MGP_CBAJ_G0023814
 protein coding gene Chr17:100865919-102040555 (-)
DBA/2J MGP_DBA2J_G0023943
 protein coding gene Chr17:88904075-89985020 (-)
FVB/NJ MGP_FVBNJ_G0023909
 protein coding gene Chr17:88450283-89525485 (-)
LP/J MGP_LPJ_G0024027
 protein coding gene Chr17:94354902-95473686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023937
 protein coding gene Chr17:100659430-101923665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024566
 protein coding gene Chr17:92612128-93724267 (-)
PWK/PhJ MGP_PWKPhJ_G0023065
 protein coding gene Chr17:88617337-89711897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022876
 protein coding gene Chr17:89356462-90483409 (-)
WSB/EiJ MGP_WSBEiJ_G0023386
 protein coding gene Chr17:93473091-94592484 (-)



Homology
more
  • Human Ortholog
    NRXN1, neurexin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRXN1, neurexin 1
  • Synonyms
    Hs.22998, PTHSL2, SCZD17
  • Links
    NCBI Gene ID: 9378
    neXtProt AC: NX_P58400, NX_Q9ULB1
    UniProt: P58400, Q9ULB1

  • Chr Location
    2p16.3; chr2:49918503-51225575 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nrxn1 mouse models; 1 with human NRXN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    167
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    984
  • Tissues
    68
  • cDNA Data
    64
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024109 Ensembl Gene Model | MGI Sequence Detail 1059441 C57BL/6J ±  kb
    transcript ENSMUST00000161402 Ensembl | MGI Sequence Detail 4953 Not Applicable  
    polypeptide ENSMUSP00000124116 Ensembl | MGI Sequence Detail 1514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 3
      cDNA 68
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915292, MGI:2442437, MGI:2444963
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 40
      Phenotypes 66
    • Earliest
      J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
    • Latest
      J:359035 Cole N, et al., Prediction-error signals in anterior cingulate cortex drive task-switching. Nat Commun. 2024 Aug 17;15(1):7088
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory